Simultaneous LC–MS/MS analysis of simvastatin, atorvastatin, rosuvastatin and their active metabolites for plasma samples of obese patients underwent gastric bypass surgery

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 164; pp. 258 - 267
• Main Authors: El-Zailik, Asma, Cheung, Lily K., Wang, Yang, Sherman, Vadim, Chow, Diana S.-L.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.02.2019
• Subjects: Adult; Atherosclerosis - etiology; Atherosclerosis - prevention & control; Atorvastatin - analogs & derivatives; Atorvastatin - blood; Atorvastatin - pharmacology; Atorvastatin - therapeutic use; Atorvastatin and metabolites; Calibration; Chromatography, High Pressure Liquid - instrumentation; Chromatography, High Pressure Liquid - methods; Female; Gastric Bypass; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias - blood; Hyperlipidemias - complications; Hyperlipidemias - drug therapy; Hyperlipidemic plasma; LC–MS/MS; Male; Middle Aged; Obese subjects from GBS; Obesity - blood; Obesity - complications; Obesity - surgery; Postoperative Period; Preoperative Period; Reproducibility of Results; Rosuvastatin; Rosuvastatin Calcium - blood; Rosuvastatin Calcium - pharmacology; Rosuvastatin Calcium - therapeutic use; Simvastatin - analogs & derivatives; Simvastatin - blood; Simvastatin - pharmacology; Simvastatin - therapeutic use; Simvastatin and metabolite; Tandem Mass Spectrometry - instrumentation; Tandem Mass Spectrometry - methods; Obese subjects from GBS; Hyperlipidemic plasma; Simvastatin and metabolite; Rosuvastatin; Atorvastatin and metabolites; LC–MS/MS

[Display omitted] •LC–MS/MS assay for simvastatin, atorvastatin, rosuvastatin, and active metabolites.•Assay was validated following FDA bioanalytical guidelines in human lipemic plasma.•Assay quantified statins and metabolites in clinical plasma of GBS obese patients. Statins, HMG-CoA reductase inh...