Systems Biology of Cancer Metastasis

• Published in: Cell systems Vol. 9; no. 2; pp. 109 - 127
• Main Authors: Suhail, Yasir, Cain, Margo P., Vanaja, Kiran, Kurywchak, Paul A., Levchenko, Andre, Kalluri, Raghu, Kshitiz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.08.2019
• Subjects: Animals; Disease Progression; Humans; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Neoplasms - metabolism; Neoplasms - pathology; Signal Transduction; Systems Biology - methods; ▪

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has...