Systems Biology of Cancer Metastasis

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has...

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Published inCell systems Vol. 9; no. 2; pp. 109 - 127
Main Authors Suhail, Yasir, Cain, Margo P., Vanaja, Kiran, Kurywchak, Paul A., Levchenko, Andre, Kalluri, Raghu, Kshitiz
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 28.08.2019
Subjects
Animals
Disease Progression
Humans
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasms - metabolism
Neoplasms - pathology
Signal Transduction
Systems Biology - methods
▪
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Abstract Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon. Cancer metastasis is a complex disease, arising from a growing tumor from which cells escape to other parts of the body. For long, cancer metastasis was considered as a combination of steps, which were studied separately, limiting our understanding of this complex disease. Here, we present the new developments and our perspective on how the new systems biology approach is changing our view of cancer metastasis as an integrated multiscale phenomenon comprising interlinked parts that allow tumors to metastasize.
AbstractList Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon. Cancer metastasis is a complex disease, arising from a growing tumor from which cells escape to other parts of the body. For long, cancer metastasis was considered as a combination of steps, which were studied separately, limiting our understanding of this complex disease. Here, we present the new developments and our perspective on how the new systems biology approach is changing our view of cancer metastasis as an integrated multiscale phenomenon comprising interlinked parts that allow tumors to metastasize.
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.
Cancer metastasis is no longer viewed as a linear cascade of events, but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. Lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multi-scale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon. Cancer metastasis is a complex disease, arising from a growing tumor from which cells escape to other parts of the body. For long, cancer metastasis was considered as a combination of steps, which were studied separately, limiting our understanding of this complex disease. Here we present the new developments, and our perspective on how the new systems biology approach is changing our view of cancer metastasis as an integrated multiscale phenomenon comprising of interlinked parts that allow tumors to metastasize.
Author Cain, Margo P.
Kshitiz
Kurywchak, Paul A.
Suhail, Yasir
Kalluri, Raghu
Vanaja, Kiran
Levchenko, Andre
AuthorAffiliation 1. Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT
3. Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX
2. Cancer Systems Biology @ Yale (CaSB@Yale), Yale University, West Haven, CT
AuthorAffiliation_xml – name: 1. Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT
– name: 3. Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX
– name: 2. Cancer Systems Biology @ Yale (CaSB@Yale), Yale University, West Haven, CT
Author_xml – sequence: 1
  givenname: Yasir
  surname: Suhail
  fullname: Suhail, Yasir
  organization: Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA
– sequence: 2
  givenname: Margo P.
  surname: Cain
  fullname: Cain, Margo P.
  organization: Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA
– sequence: 3
  givenname: Kiran
  surname: Vanaja
  fullname: Vanaja, Kiran
  organization: Cancer Systems Biology @ Yale (CaSB@Yale), Yale University, West Haven, CT, USA
– sequence: 4
  givenname: Paul A.
  surname: Kurywchak
  fullname: Kurywchak, Paul A.
  organization: Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA
– sequence: 5
  givenname: Andre
  surname: Levchenko
  fullname: Levchenko, Andre
  organization: Cancer Systems Biology @ Yale (CaSB@Yale), Yale University, West Haven, CT, USA
– sequence: 6
  givenname: Raghu
  surname: Kalluri
  fullname: Kalluri, Raghu
  organization: Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA
– sequence: 7
  surname: Kshitiz
  fullname: Kshitiz
  email: kshitiz@uchc.edu
  organization: Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31465728$$D View this record in MEDLINE/PubMed
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Snippet Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully...
Cancer metastasis is no longer viewed as a linear cascade of events, but rather as a series of concurrent, partially overlapping processes, as successfully...
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SubjectTerms Animals
Disease Progression
Humans
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasms - metabolism
Neoplasms - pathology
Signal Transduction
Systems Biology - methods
Title Systems Biology of Cancer Metastasis
URI https://dx.doi.org/10.1016/j.cels.2019.07.003
https://www.ncbi.nlm.nih.gov/pubmed/31465728
https://www.proquest.com/docview/2283110677
https://pubmed.ncbi.nlm.nih.gov/PMC6716621
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