Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition - Cornelison, Jeffery L.; Cato, Michael L.; Johnson, Alyssa M.; D'Agostino, Emma H.; Melchers, Diana; Patel, Anamika B.; Mays, Suzanne G.; Houtman, René; Ortlund, Eric A.; Jui, Nathan T. (Bioorganic & medicinal chemistry letters, 2020)
Keywords: Agonist; Aniline Compounds - chemical synthesis; Aniline Compounds - chemistry; Aniline Compounds - pharmacology; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Dose-Response Relationship, Drug; Drug Development; Humans; Life Sciences & Biomedicine; LRH-1; Metabolic disease; Molecular Docking Simulation; Molecular Structure; Nuclear receptor; Oxidation-Reduction; Pharmacology & Pharmacy; Photochemical Processes; Photoredox; Physical Sciences; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - genetics; Science & Technology; Structure-Activity Relationship; Metabolic disease; Nuclear receptor; Agonist; LRH-1; Photoredox; INSERTION; QUATERNARY CARBONS; RADICALS