Injury-induced insulin resistance in adipose tissue
► A rodent model of critical illness diabetes was used. ► Adipose tissue became acutely insulin resistant in this model. ► Within minutes, there was a reduction in insulin-induced phosphorylation of IR, IRS-1, Akt and GSK-3β. ► Insulin resistance occurred rapidly in adipose tissue, prior to the insu...
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| Published in | Biochemical and biophysical research communications Vol. 421; no. 3; pp. 442 - 448 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
11.05.2012
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| Abstract | ► A rodent model of critical illness diabetes was used. ► Adipose tissue became acutely insulin resistant in this model. ► Within minutes, there was a reduction in insulin-induced phosphorylation of IR, IRS-1, Akt and GSK-3β. ► Insulin resistance occurred rapidly in adipose tissue, prior to the insulin resistance in skeletal muscle.
Hyperglycemia and insulin resistance are common findings in critical illness. Patients in the surgical ICU are frequently treated for this ‘critical illness diabetes’ with intensive insulin therapy, resulting in a substantial reduction in morbidity and mortality. Adipose tissue is an important insulin target tissue, but it is not known whether adipose tissue is affected by critical illness diabetes. In the present study, a rodent model of critical illness diabetes was used to determine whether adipose tissue becomes acutely insulin resistant and how insulin signaling pathways are being affected. There was a reduction in insulin-induced phosphorylation of IR, IRS-1, Akt and GSK-3β. Since insulin resistance occurs rapidly in adipose tissue, but before the insulin resistance in skeletal muscle, it may play a role in the initial development of critical illness diabetes. |
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| AbstractList | Hyperglycemia and insulin resistance are common findings in critical illness. Patients in the surgical ICU are frequently treated for this ‘critical illness diabetes’ with intensive insulin therapy, resulting in a substantial reduction in morbidity and mortality. Adipose tissue is an important insulin target tissue, but it is not known whether adipose tissue is affected by critical illness diabetes. In the present study, a rodent model of critical illness diabetes was used to determine whether adipose tissue becomes acutely insulin resistant and how insulin signaling pathways are being affected. There was a reduction in insulin-induced phosphorylation of IR, IRS-1, Akt and GSK-3β. Since insulin resistance occurs rapidly in adipose tissue, but before the insulin resistance in skeletal muscle, it may play a role in the initial development of critical illness diabetes. ► A rodent model of critical illness diabetes was used. ► Adipose tissue became acutely insulin resistant in this model. ► Within minutes, there was a reduction in insulin-induced phosphorylation of IR, IRS-1, Akt and GSK-3β. ► Insulin resistance occurred rapidly in adipose tissue, prior to the insulin resistance in skeletal muscle. Hyperglycemia and insulin resistance are common findings in critical illness. Patients in the surgical ICU are frequently treated for this ‘critical illness diabetes’ with intensive insulin therapy, resulting in a substantial reduction in morbidity and mortality. Adipose tissue is an important insulin target tissue, but it is not known whether adipose tissue is affected by critical illness diabetes. In the present study, a rodent model of critical illness diabetes was used to determine whether adipose tissue becomes acutely insulin resistant and how insulin signaling pathways are being affected. There was a reduction in insulin-induced phosphorylation of IR, IRS-1, Akt and GSK-3β. Since insulin resistance occurs rapidly in adipose tissue, but before the insulin resistance in skeletal muscle, it may play a role in the initial development of critical illness diabetes. |
| Author | Franklin, John L. Williams, Vanessa L. Messina, Joseph L. Hardy, Robert W. Martin, Rachel E. |
| AuthorAffiliation | 1 Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2 Department of Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 4 Veterans Affairs Medical Center, Birmingham, Alabama 35233 3 Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 |
| AuthorAffiliation_xml | – name: 4 Veterans Affairs Medical Center, Birmingham, Alabama 35233 – name: 2 Department of Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 – name: 3 Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 – name: 1 Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama 35294 |
| Author_xml | – sequence: 1 givenname: Vanessa L. surname: Williams fullname: Williams, Vanessa L. organization: Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA – sequence: 2 givenname: Rachel E. surname: Martin fullname: Martin, Rachel E. organization: Department of Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA – sequence: 3 givenname: John L. surname: Franklin fullname: Franklin, John L. organization: Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA – sequence: 4 givenname: Robert W. surname: Hardy fullname: Hardy, Robert W. organization: Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA – sequence: 5 givenname: Joseph L. surname: Messina fullname: Messina, Joseph L. email: messinaj@uab.edu organization: Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA |
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| Keywords | Insulin resistance Critical illness diabetes Adipose tissue Hemorrhage Injury Insulin signaling |
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| Snippet | ► A rodent model of critical illness diabetes was used. ► Adipose tissue became acutely insulin resistant in this model. ► Within minutes, there was a... Hyperglycemia and insulin resistance are common findings in critical illness. Patients in the surgical ICU are frequently treated for this 'critical illness... Hyperglycemia and insulin resistance are common findings in critical illness. Patients in the surgical ICU are frequently treated for this ‘critical illness... |
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| SubjectTerms | Adipose tissue Adipose Tissue - injuries Adipose Tissue - metabolism Animals Critical Illness Critical illness diabetes Diabetes Mellitus - etiology Disease Models, Animal Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hemorrhage Injury Insulin - metabolism Insulin - pharmacology Insulin Resistance Insulin signaling Male Phosphorylation Rats Rats, Sprague-Dawley Serine - metabolism |
| Title | Injury-induced insulin resistance in adipose tissue |
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