A Mouse Model of Zika Virus Pathogenesis

• Published in: Cell host & microbe Vol. 19; no. 5; pp. 720 - 730
• Main Authors: Lazear, Helen M., Govero, Jennifer, Smith, Amber M., Platt, Derek J., Fernandez, Estefania, Miner, Jonathan J., Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.05.2016
• Subjects: Animals; Cercopithecus aethiops; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Vero Cells; Zika Virus - pathogenicity; Zika Virus Infection - immunology; Zika Virus Infection - prevention & control; Zika Virus Infection - virology

The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including Guillain-Barré syndrome and birth defects, has brought an urgent need for animal models. We evaluated infection and pathogenesis with contemporary and historical ZIKV strains in immunocompetent mice and mice lacking c...