AIFM2 blocks ferroptosis independent of ubiquinol metabolism

• Published in: Biochemical and biophysical research communications Vol. 523; no. 4; pp. 966 - 971
• Main Authors: Dai, Enyong, Zhang, Wenlong, Cong, Dan, Kang, Rui, Wang, Jing, Tang, Daolin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.03.2020
• Subjects: AIFM2; Animals; antineoplastic activity; antioxidants; Antioxidants - metabolism; Apoptosis Regulatory Proteins - metabolism; Cell Line, Tumor; Cell Membrane - metabolism; coenzyme Q10; CoQ10; Endosomal Sorting Complexes Required for Transport - metabolism; ESCRT; Ferroptosis; Humans; Lipid peroxidation; metabolism; mice; Mice, Nude; Mitochondrial Proteins - metabolism; neoplasm cells; neoplasms; plasma membrane; Ubiquinol; Ubiquinone - analogs & derivatives; Ubiquinone - metabolism; xenotransplantation; NFE2L2/NRF2; ESCRT; GPX4; CoQ10; Lipid peroxidation; Ferroptosis; ACSL4; HMGB1; MDA; SLC7A11; Ubiquinol; AIFM2; GSH; CHMP5

Ferroptosis is a multi-step regulated cell death that is characterized by excessive iron accumulation and lipid peroxidation. Cancer cells can acquire resistance to ferroptosis by the upregulation of anti-ferroptotic proteins or by the downregulation of pro-ferroptotic proteins. Apoptosis-inducing f...