Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution

• Published in: The New England journal of medicine Vol. 383; no. 20; pp. 1941 - 1950
• Main Authors: Doan, Thuy, Worden, Lee, Hinterwirth, Armin, Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Zhong, Lina, Chen, Cindi, Cook, Catherine, Lebas, Elodie, O’Brien, Kieran S, Oldenburg, Catherine E, Chow, Eric D, Porco, Travis C, Lipsitch, Marc, Keenan, Jeremy D, Lietman, Thomas M
• Format: Journal Article
• Language: English
• Published: Boston Massachusetts Medical Society 12.11.2020
• Subjects: Antibiotic resistance; Antibiotics; Antimicrobial resistance; Azithromycin; Child mortality; Children; Deoxyribonucleic acid; DNA; Drug resistance; Genetic testing; Genomes; Intervention; Rectum; Streptococcus infections; β-Lactam antibiotics; Niger; United States > US; California

Villages in Niger were randomly assigned to offer azithromycin or placebo to children 1 to 59 months of age every 6 months for 4 years. Stool samples collected at 36 and 48 months showed that antibiotic resistance was more common among children living in villages that received azithromycin than amon...