A compendium of adenovirus genetic modifications for enhanced replication, oncolysis, and tumor immunosurveillance in cancer therapy

• Published in: Gene Vol. 679; pp. 11 - 18
• Main Authors: Stepanenko, Aleksei A., Chekhonin, Vladimir P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.12.2018
• Subjects: Adenoviridae; Adenovirus death protein; amino acids; Cancer therapy; Coxsackievirus and adenovirus receptor; Cytotoxic T cells; death; Dicer; E1A protein; E3-19K; Endoplasmic reticulum; epitopes; gene overexpression; genetic engineering; I-leader sequence; Immunotherapy; major histocompatibility complex; Major late promoter; MHCI; MICA/MICB; Minor core protein V; mutation; Natural killer cells; neoplasms; NKG2D; Oncolytic virotherapy; p19 tomato bushy stunt protein; progeny; proteins; RNA interference; SUMOylation; T-lymphocytes; therapeutics; tomatoes; VA RNA; viruses; MICA/MICB; TAP; Ad; MHCI/HLA; E3-19K; MTT; ADP; MLP; NKG2D; E1A protein; Major late promoter; Immunotherapy; Oncolytic virotherapy; p19 tomato bushy stunt protein; Natural killer cells; RISC; SUMO; Dicer; MHCI; I-leader sequence; Coxsackievirus and adenovirus receptor; Adenovirus death protein; VA RNA; CAR; KIR; NKT; PKR; Cancer therapy; Cytotoxic T cells; SUMOylation; NK; Endoplasmic reticulum; Minor core protein V

In this review, we specifically focus on genetic modifications of oncolytic adenovirus 5 (Ad5)-based vectors that enhance replication, oncolysis/spread, and virus-mediated tumor immunosurveillance. The finding of negative regulation of minor core protein V by SUMOylation led to the identification of...