Immunoreactive endothelin in bronchial biopsy specimens: Increased expression in asthma and modulation by corticosteroid therapy

• Published in: Journal of allergy and clinical immunology Vol. 100; no. 4; pp. 544 - 552
• Main Authors: Redington, Anthony E., Springall, David R., Meng, Qing-Hai, Tuck a, Angela B., Holgate, Stephen T., Polak, Julia M., Howarth, Peter H.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.1997; Elsevier
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists - therapeutic use; Adult; Asthma; Asthma - drug therapy; Asthma - immunology; Asthma - metabolism; Biological and medical sciences; Biopsy; Bronchi - metabolism; Bronchi - pathology; bronchial biopsy; Chronic obstructive pulmonary disease, asthma; collagen; Collagen - metabolism; corticosteroids; endothelin; Endothelins - biosynthesis; Endothelins - immunology; Epithelium - metabolism; Female; Humans; inflammation; Male; Medical sciences; Pneumology; remodeling; PBS; endothelin; BSA; remodeling; corticosteroids; inflammation; bronchial biopsy; collagen; BAL; Asthma; ET; Human; Corticosteroid; Agonist; Endothelin; Pathophysiology; Respiratory disease; Bronchodilator; Peptide hormone; Antiinflammatory agent; Bronchus; β2-Adrenergic receptor; Chemotherapy; Treatment; Immunoreactive form; Biopsy; Vasoconstrictor agent; Obstructive pulmonary disease; Comparative study

Background: The human endothelin (ET) family comprises three 21-amino-acid peptides, which are potent bronchoconstrictors and have a number of other biologic properties relevant to the pathophysiology of asthma. Objective: We sought to compare the expression of immunoreactive ET in bronchial biopsy...