Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes

• Published in: Clinical lung cancer Vol. 18; no. 1; pp. e1 - e11
• Main Authors: Murton, Andrew J, Maddocks, Matthew, Stephens, Francis B, Marimuthu, Kanagaraj, England, Ruth, Wilcock, Andrew
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2017
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Aged; Cachexia - etiology; Cachexia - metabolism; Cachexia - pathology; Carcinoma, Non-Small-Cell Lung - complications; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Squamous Cell - complications; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Case-Control Studies; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Lipid metabolism; Lipids - analysis; Lung Neoplasms - complications; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; mTOR signaling; Muscle protein synthesis; Muscle Proteins - metabolism; Neoplasm Staging; Prognosis; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Pulmonary/Respiratory; Ubiquitin proteasome system; ubiquitin proteasome system; mTOR signalling; Muscle protein synthesis; proteolysis; cachexia; Lipid metabolism; mTOR signaling; Proteolysis; Ubiquitin proteasome system

Abstract Introduction Loss of muscle is common in patients with advanced non-small cell lung cancer (NSCLC), and contributes to the high morbidity and mortality of this group. The exact mechanisms behind the loss of muscle are unclear. Methods To investigate this, 4 patients with stage IV NSCLC meet...