Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells

• Published in: Cancer research (Chicago, Ill.) Vol. 74; no. 20; pp. 5746 - 5757
• Main Authors: Wang, Bin, Wang, Qiang, Wang, Zhe, Jiang, Jun, Yu, Shi-Cang, Ping, Yi-Fang, Yang, Jing, Xu, Sen-Lin, Ye, Xian-Zong, Xu, Chuan, Yang, Lang, Qian, Cheng, Wang, Ji Ming, Cui, You-Hong, Zhang, Xia, Bian, Xiu-Wu
• Format: Journal Article
• Language: English
• Published: United States 15.10.2014
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I - metabolism; Humans; K562 Cells; Killer Cells, Natural - immunology; Lung Neoplasms - immunology; Lung Neoplasms - secondary; Mice, Inbred NOD; Mice, SCID; MicroRNAs - metabolism; Middle Aged; Neoplasm Transplantation; Neoplastic Stem Cells - immunology; Neoplastic Stem Cells - pathology; RNA Interference; Tumor Escape; Young Adult

Breast cancer stem-like cells (BCSC) are crucial for metastasis but the underlying mechanisms remain elusive. Here, we report that tumor-infiltrating natural killer (NK) cells failed to limit metastasis and were not associated with improved therapeutic outcome of BCSC-rich breast cancer. Primary BCS...