Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys

• Published in: Cell metabolism Vol. 27; no. 3; pp. 677 - 688.e5
• Main Authors: Rhoads, Timothy W., Burhans, Maggie S., Chen, Vincent B., Hutchins, Paul D., Rush, Matthew J.P., Clark, Josef P., Stark, Jaime L., McIlwain, Sean J., Eghbalnia, Hamid R., Pavelec, Derek M., Ong, Irene M., Denu, John M., Markley, John L., Coon, Joshua J., Colman, Ricki J., Anderson, Rozalyn M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.03.2018
• Subjects: aging; caloric restriction; lipid metabolism; metabolism; rhesus macaque; RNA processing; rhesus macaque; metabolism; caloric restriction; aging; RNA processing; lipid metabolism

Caloric restriction (CR) extends lifespan and delays the onset of age-related disorders in diverse species. Metabolic regulatory pathways have been implicated in the mechanisms of CR, but the molecular details have not been elucidated. Here, we show that CR engages RNA processing of genes associated...