Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes

• Published in: Journal of theoretical biology Vol. 383; pp. 93 - 105
• Main Authors: Jaberi-Douraki, Majid, Pietropaolo, Massimo, Khadra, Anmar
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21.10.2015
• Subjects: Antibody Affinity - immunology; Autoimmunity - immunology; Avidity-dependent dominance; Diabetes Mellitus, Type 1 - immunology; Disease Progression; Honeymoon period; Humans; Immune Tolerance; Immunomodulation; Inter- and intra-clonal competition; Mathematical model; Models, Immunological; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Regulatory - immunology; Avidity-dependent dominance; Honeymoon period; Inter- and intra-clonal competition; Mathematical model; Immunomodulation

Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-secreting pancreatic β cells, leading to abolition of insulin secretion and onset of diabetes. Cytotoxic CD4+ and CD8+ T cells, activated by antigen presenting cells (APCs), are both implicated in disease ons...