Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface

• Published in: Med (New York, N.Y. : Online) Vol. 2; no. 5; pp. 591 - 610.e10
• Main Authors: Lu-Culligan, Alice, Chavan, Arun R., Vijayakumar, Pavithra, Irshaid, Lina, Courchaine, Edward M., Milano, Kristin M., Tang, Zhonghua, Pope, Scott D., Song, Eric, Vogels, Chantal B.F., Lu-Culligan, William J., Campbell, Katherine H., Casanovas-Massana, Arnau, Bermejo, Santos, Toothaker, Jessica M., Lee, Hannah J., Liu, Feimei, Schulz, Wade, Fournier, John, Muenker, M. Catherine, Moore, Adam J., Konnikova, Liza, Neugebauer, Karla M., Ring, Aaron, Grubaugh, Nathan D., Ko, Albert I., Morotti, Raffaella, Guller, Seth, Kliman, Harvey J., Iwasaki, Akiko, Farhadian, Shelli F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.05.2021
• Subjects: Angiotensin-Converting Enzyme 2 - genetics; Clinical and Translational; COVID-19; Female; Humans; placenta; Placenta - metabolism; Pregnancy; Pregnancy Complications, Infectious - metabolism; SARS-CoV-2; COVID-19; placenta; SARS-CoV-2; Translation to patients; pregnancy

Pregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and its potential effect on the developing fetus is not well understood. We assessed placental histology, ACE2 expression, and viral and immu...