Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH

• Published in: Antioxidants & redox signaling Vol. 10; no. 2; p. 277
• Main Authors: O'Neill, Heidi C, Rancourt, Raymond C, White, Carl W
• Format: Journal Article
• Language: English
• Published: United States 01.02.2008
• Subjects: Bacterial Infections - prevention & control; Folic Acid - pharmacology; Glucosephosphate Dehydrogenase - blood; Humans; Kinetics; NADP - pharmacology; Neutrophils - drug effects; Neutrophils - microbiology; Neutrophils - physiology; Oxygen Consumption; Peroxidase - blood; Reactive Oxygen Species - metabolism; Respiratory Burst - drug effects; Respiratory Burst - physiology; Superoxides - blood; Thioctic Acid - pharmacology

Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking in the lung's epithelial lining fluid in lun...