Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration

• Published in: International immunology Vol. 17; no. 6; pp. 759 - 768
• Main Authors: Miyamoto, Takeshi, Kaneko, Takaaki, Yamashita, Masakatsu, Tenda, Yoshiyuki, Inami, Masamichi, Suzuki, Akane, Ishii, Sohtaro, Kimura, Motoko, Hashimoto, Kahoko, Shimada, Hideaki, Yahata, Hiroshi, Ochiai, Takenori, Saito, Izumu, DeGregori, James, Nakayama, Toshinori
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2005; Oxford Publishing Limited (England)
• Subjects: Ad-GFP adenovirus vector containing EGFP gene; Ad-hIL-10 adenovirus vector containing human IL-10 gene; Ad-LacZ adenovirus vector containing lacZ gene; Adenoviridae; Adenovirus; Animals; Bm1; Bm1 B6.C-H2bm1/ByJ; CAR Tg; CAR Coxsackie virus and adenovirus receptor; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Coxsackievirus; CsA cyclosporin A; DC dendritic cell; Enterovirus - genetics; gene therapy; Gene Transfer Techniques; Graft Survival - immunology; hIL-10 human IL-10; i.f.u. infectious units; Immunosuppression; Interleukin-10 - biosynthesis; Interleukin-10 - genetics; Interleukin-10 - immunology; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; POD post-operation day; skin graft; Skin Transplantation - immunology; Spleen - cytology; Spleen - immunology; T-Lymphocyte Subsets - immunology; Tacrolimus - pharmacology; Tg transgenic; Th2 Cells - immunology

Both CD4 and CD8 T cells play crucial roles in immune responses in transplantation. Immunosuppressive drugs, such as FK506 and cyclosporin A, block the priming of alloreactive CD4 Th cells and the subsequent induction of allospecific CD8 cytotoxic effector T cells and inhibit allograft rejection. Ho...