Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: Same or different disease?

• Published in: Progress in retinal and eye research Vol. 29; no. 1; pp. 19 - 29
• Main Authors: Laude, Augustinus, Cackett, Peter D., Vithana, Eranga N., Yeo, Ian Y., Wong, Doric, Koh, Adrian H., Wong, Tien Y., Aung, Tin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 2010
• Subjects: Age Factors; Choroid - blood supply; Choroid - pathology; Choroid - physiopathology; Choroidal neovascularization; Complement factor H; Genetic Predisposition to Disease; Humans; Indocyanine green angiography; Neovascular age-related macular degeneration; Optical coherence tomography; Peripheral Vascular Diseases - epidemiology; Peripheral Vascular Diseases - etiology; Peripheral Vascular Diseases - pathology; Peripheral Vascular Diseases - physiopathology; Polypoidal choroidal vasculopathy; Polyps - pathology; Polyps - physiopathology; Risk Factors; Smoking; Vascular endothelial growth factor; Wet Macular Degeneration - epidemiology; Wet Macular Degeneration - etiology; Wet Macular Degeneration - pathology; Wet Macular Degeneration - physiopathology; Polypoidal choroidal vasculopathy; Indocyanine green angiography; Complement factor H; Choroidal neovascularization; Optical coherence tomography; Neovascular age-related macular degeneration; Vascular endothelial growth factor; Smoking

Neovascular age-related macular degeneration (nAMD) is the commonest cause of severe visual impairment in older adults in Caucasian white populations. Polypoidal choroidal vasculopathy (PCV) has been described as a separate clinical entity differing from nAMD and other macular diseases associated wi...