Variation of BOLD hemodynamic responses across subjects and brain regions and their effects on statistical analyses

• Published in: NeuroImage (Orlando, Fla.) Vol. 21; no. 4; pp. 1639 - 1651
• Main Authors: Handwerker, Daniel A., Ollinger, John M., D'Esposito, Mark
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2004; Elsevier Limited
• Subjects: Activation latency; Adolescent; Adult; Analysis of Variance; Brain - blood supply; Brain Mapping; Cerebral Cortex - physiology; Dominance, Cerebral - physiology; Echo-Planar Imaging; Estimates; Evoked Potentials - physiology; Experiments; Female; fMRI; Frontal Lobe - physiology; Functional neuroimaging; Hemodynamic response function; Hemodynamics - physiology; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Linear Models; Linear regression; Magnetic Resonance Imaging - statistics & numerical data; Male; Mathematical Computing; Motor Cortex - physiology; Oxygen - blood; Pattern Recognition, Visual - physiology; Psychomotor Performance - physiology; Random effects; Reaction Time - physiology; Reflex - physiology; Saccades; Saccades - physiology; Statistics as Topic; Studies; Time series; Visual areas; Visual Cortex - physiology; fMRI; Saccades; Linear regression; Functional neuroimaging; Random effects; Activation latency; Hemodynamic response function; Visual areas

Estimates of hemodynamic response functions (HRF) are often integral parts of event-related fMRI analyses. Although HRFs vary across individuals and brain regions, few studies have investigated how variations affect the results of statistical analyses using the general linear model (GLM). In this st...