Rheological evaluation of Gelrite® in situ gels for ophthalmic use

• Published in: European journal of pharmaceutical sciences Vol. 6; no. 2; pp. 113 - 119
• Main Authors: Carlfors, Johan, Edsman, Katarina, Petersson, Roger, Jörnving, Katarina
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.04.1998; Elsevier
• Subjects: Animals; Biological and medical sciences; Eye - drug effects; Eye - metabolism; Gel; Gelrite; General pharmacology; Humans; Medical sciences; Ocular drug delivery; Ophthalmic Solutions - chemistry; Ophthalmic Solutions - metabolism; Ophthalmic Solutions - toxicity; Osmolality; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polysaccharides, Bacterial - chemistry; Polysaccharides, Bacterial - metabolism; Polysaccharides, Bacterial - toxicity; Rabbits; Residence time; Rheology; Residence time; Rheology; Gelrite; Ocular drug delivery; Osmolality; Gel; Human; Viscosity; Cornea; Pharmaceutical technology; Elasticity; Rabbit; Lagomorpha; Colloidal gel; Eye; Vertebrata; Mammalia; Animal; Dosage form; Hydrogel; Intraocular administration; Rheological properties

One of the reasons for the relatively low bioavailability of conventional eye drops is their short precorneal contact times. In situ gels are promising ocular drug delivery systems since they are conveniently dropped into the eye as a liquid whereafter they undergo a transition into a gel. Due to th...