Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells

• Published in: Biochemical and biophysical research communications Vol. 489; no. 4; pp. 466 - 471
• Main Authors: Yamashita, Nobuko, Yashiro, Masato, Ogawa, Hirohito, Namba, Hikaru, Nosaka, Nobuyuki, Fujii, Yousuke, Morishima, Tsuneo, Tsukahara, Hirokazu, Yamada, Masao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.08.2017
• Subjects: Amidohydrolases - genetics; Amidohydrolases - metabolism; Biocatalysis; biochemical pathways; blood; Cell Line, Tumor; Cysteamine; Cysteamine - pharmacology; Cytokines - metabolism; Dose-Response Relationship, Drug; epithelium; gene expression; genes; GPI-Linked Proteins - genetics; GPI-Linked Proteins - metabolism; Humans; influenza; Influenza A virus; Influenza A virus - drug effects; Influenza A virus - metabolism; Influenza virus; interleukin-1beta; messenger RNA; metabolites; neoplasm cells; Pantetheine; pantothenic acid; Pantothenic Acid - pharmacology; patients; pneumonia; respiratory system; RNA, Messenger - genetics; RNA, Messenger - metabolism; Structure-Activity Relationship; transcription (genetics); tumor necrosis factor-alpha; Up-Regulation; Vanin-1 (VNN1); virus replication; Virus Replication - drug effects; Pantetheine; Cysteamine (PubChem CID: 6058); VNN1; M1; Influenza virus; Pantetheine (PubChem CID: 439322); Cysteamine; Vanin-1 (VNN1); IV; IAV

Our previous analysis of gene expression profiles in the peripheral blood from patients with influenza A (H1N1) pdm09 pneumonia revealed elevated transcription levels of the vanin-1 (vascular non-inflammatory molecule 1, VNN1) gene, which encodes an epithelial ectoenzyme with pantetheinase activity...