Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells - Yamashita, Nobuko; Yashiro, Masato; Ogawa, Hirohito; Namba, Hikaru; Nosaka, Nobuyuki; Fujii, Yousuke; Morishima, Tsuneo; Tsukahara, Hirokazu; Yamada, Masao (Biochemical and biophysical research communications, 2017)
Keywords: Amidohydrolases - genetics; Amidohydrolases - metabolism; Biocatalysis; biochemical pathways; blood; Cell Line, Tumor; Cysteamine; Cysteamine - pharmacology; Cytokines - metabolism; Dose-Response Relationship, Drug; epithelium; gene expression; genes; GPI-Linked Proteins - genetics; GPI-Linked Proteins - metabolism; Humans; influenza; Influenza A virus; Influenza A virus - drug effects; Influenza A virus - metabolism; Influenza virus; interleukin-1beta; messenger RNA; metabolites; neoplasm cells; Pantetheine; pantothenic acid; Pantothenic Acid - pharmacology; patients; pneumonia; respiratory system; RNA, Messenger - genetics; RNA, Messenger - metabolism; Structure-Activity Relationship; transcription (genetics); tumor necrosis factor-alpha; Up-Regulation; Vanin-1 (VNN1); virus replication; Virus Replication - drug effects; Pantetheine; Cysteamine (PubChem CID: 6058); VNN1; M1; Influenza virus; Pantetheine (PubChem CID: 439322); Cysteamine; Vanin-1 (VNN1); IV; IAV