(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2

• Published in: International journal of molecular sciences Vol. 22; no. 17; p. 9289
• Main Authors: Wang, Yu-Shi, Chen, Chen, Zhang, Shi-Yin, Li, Yang, Jin, Ying-Hua
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2021; MDPI
• Subjects: (20S)G-Rh2; Angiogenesis; Annexin A2; Cancer; Cell activation; Cell culture; Cell cycle; Cell division; Cell growth; Cytokines; Gene expression; Kinases; Medical prognosis; Metastasis; Mutation; Phosphorylation; Protein-tyrosine kinase; Proteins; Signal processing; STAT3; Stat3 protein; Transcription activation; Transcription factors; Transducers; Tumor cells; Tumors; Tyrosine; Vascular endothelial growth factor; VEGF

Signal transducers and activators of transcription 3 (STAT3) acts as a transcriptional signal transducer, converting cytokine stimulation into specific gene expression. In tumor cells, aberrant activation of the tyrosine kinase pathway leads to excessive and continuous activation of STAT3, which pro...