Interferon Induction: A Conformational Hypothesis

The ability of polynucleotides or polynucleotide duplexes such as poly(I)· poly(C) to induce interferon production is proposed to depend on the existence of certain stable glycosidic orientations. It appears that a slight increase in instability of 1-3 kcal/mole (1 cal = 4.184 J) in the conformation...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 76; no. 3; pp. 1018 - 1021
Main Authors Miles, Douglas L., Miles, Daniel W., Eyring, Henry
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.03.1979
National Acad Sciences
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The ability of polynucleotides or polynucleotide duplexes such as poly(I)· poly(C) to induce interferon production is proposed to depend on the existence of certain stable glycosidic orientations. It appears that a slight increase in instability of 1-3 kcal/mole (1 cal = 4.184 J) in the conformational regions near 20 degrees, 80 degrees, and 160 degrees leads to a loss of potency with respect to interferon induction. Thus, it is proposed that, for a polynucleotide to exist in the overall conformation necessary for interferon induction, stability of glycosidic orientations near 20 degrees, 80 degrees, and 160 degrees may be necessary to confer flexibility and activity on polynucleotide structures. This proposed conformational triad of stable conformational regions essential to interferon induction is based on the results of conformational energy calculations of the glycosidic rotational profiles of adenosine, 7-deazaadenosine, inosine, and 7-deazainosine, as well as the conformational properties of other purine nucleoside analogs, and on inferences derived from calculations about the conformational effect in polynucleotides of removing the 2′-OH group.
AbstractList The ability of polynucleotides or polynucleotide duplexes such as poly(I).poly(C) to induce interferon production is proposed to depend on the existence of certain stable glycosidic orientations. It appears that a slight increase in instability of 1--3 kcal/mole (1 cal = 4.184 J) in the conformational regions near 20 degrees, 80 degrees, and 160 degrees leads to a loss of potency with respect to interferon induction. Thus, it is proposed that, for a polynucleotide to exist in the overall conformation necessary for interferon induction, stability of glycosidic orientations near 20 degrees, 80 degrees, and 160 degrees may be necessary to confer flexibility and activity on polynucleotide structures. This proposed conformational triad of stable conformational regions essential to interferon induction is based on the results of conformational energy calculations of the glycoside rotational profiles of adenosine, 7-deazaadenosine, inosine, and 7-deazainosine, as well as the conformational properties of other purine nucleoside analogs, and on inferences derived from calculations about the conformational effect in polynucleotides of removing the 2'-OH group.
The ability of polynucleotides or polynucleotide duplexes such as poly(I)· poly(C) to induce interferon production is proposed to depend on the existence of certain stable glycosidic orientations. It appears that a slight increase in instability of 1-3 kcal/mole (1 cal = 4.184 J) in the conformational regions near 20 degrees, 80 degrees, and 160 degrees leads to a loss of potency with respect to interferon induction. Thus, it is proposed that, for a polynucleotide to exist in the overall conformation necessary for interferon induction, stability of glycosidic orientations near 20 degrees, 80 degrees, and 160 degrees may be necessary to confer flexibility and activity on polynucleotide structures. This proposed conformational triad of stable conformational regions essential to interferon induction is based on the results of conformational energy calculations of the glycosidic rotational profiles of adenosine, 7-deazaadenosine, inosine, and 7-deazainosine, as well as the conformational properties of other purine nucleoside analogs, and on inferences derived from calculations about the conformational effect in polynucleotides of removing the 2′-OH group.
Author Miles, Daniel W.
Eyring, Henry
Miles, Douglas L.
Author_xml – sequence: 1
  givenname: Douglas L.
  surname: Miles
  fullname: Miles, Douglas L.
– sequence: 2
  givenname: Daniel W.
  surname: Miles
  fullname: Miles, Daniel W.
– sequence: 3
  givenname: Henry
  surname: Eyring
  fullname: Eyring, Henry
BackLink https://www.ncbi.nlm.nih.gov/pubmed/286290$$D View this record in MEDLINE/PubMed
BookMark eNp9kE1rGzEURUVx2zhpt12EFLzybhxp9B3IIpimMQS6SddCo3nTjBlLjqQJ8b_vDHaNs-lKPO65T49zjiY-eEDoG8ELgiW93nqbFlIs6DAS9QFNCdakEEzjCZpiXMpCsZKdofOU1hhjzRX-jD6VSpQaTxFZ-QyxgRj8bOXr3uU2-JvZ3WwZfBPixo6z7WYPu23Iz5Da9AV9bGyX4OvhvUC_7388LR-Kx18_V8u7x8IxznNhK0FLbAkHzhoLtgLmCCfaaiUrV0teSwGKgSQ1FbhyXAEF4QTjDceWlfQC3e73bvtqA7UDn6PtzDa2Gxt3JtjWvE98-2z-hFdDFSVSDf35oR_DSw8pm02bHHSd9RD6ZCTjgx2tB3CxB10MKUVojn8QbEbFZlRspDDUjIqHwtXpZUd873SIvx_isfYvPK3P_5ebpu-6DG95AC_34DrlEI-k0CUp6V9j_prG
CitedBy_id crossref_primary_10_1111_j_1432_1033_1980_tb04648_x
crossref_primary_10_1038_nsmb_1453
crossref_primary_10_1002_jpp_381
crossref_primary_10_1002_zfch_19820221002
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1073/pnas.76.3.1018
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

CrossRef


MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
EISSN 1091-6490
EndPage 1021
ExternalDocumentID 10_1073_pnas_76_3_1018
286290
76_3_1018
69212
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, U.S. Gov't, P.H.S
Journal Article
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
123
29P
2AX
2FS
2WC
4.4
53G
5RE
5VS
6TJ
85S
AACGO
AAFWJ
AANCE
ABBHK
ABOCM
ABPLY
ABPPZ
ABTLG
ABXSQ
ABZEH
ACGOD
ACIWK
ACNCT
ACPRK
ADACV
ADULT
AENEX
AEUPB
AEXZC
AFFNX
AFOSN
AFRAH
ALMA_UNASSIGNED_HOLDINGS
AQVQM
AS~
CS3
D0L
DCCCD
DIK
DOOOF
DU5
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HGD
HH5
HQ3
HTVGU
HYE
IPSME
JAAYA
JBMMH
JENOY
JHFFW
JKQEH
JLS
JLXEF
JPM
JSG
JSODD
JST
KQ8
L7B
LU7
MVM
N9A
NEJ
N~3
O9-
OK1
P-O
PNE
PQQKQ
R.V
RHF
RHI
RNA
RNS
RPM
RXW
SA0
SJN
TN5
UKR
VOH
VQA
W8F
WH7
WHG
WOQ
WOW
X7M
XSW
ZCA
ZCG
~02
~KM
-
02
08R
0R
1AW
55
AAPBV
ABFLS
ABPTK
ADACO
ADZLD
AFDAS
AJYGW
AS
ASUFR
DNJUQ
DWIUU
DZ
F20
GJ
KM
OHM
PQEST
X
XHC
ZA5
3O-
692
79B
AAYJJ
ACKIV
BKOMP
CGR
CUY
CVF
ECM
EIF
NHB
NPM
TAE
Y6R
YBH
YKV
YSK
AAYXX
CITATION
7X8
5PM
ID FETCH-LOGICAL-c455t-ab6320a15e54faeabe4c1519a987bcd75d76e84e71d360bc58e3e6c645f50a423
IEDL.DBID RPM
ISSN 0027-8424
IngestDate Tue Sep 17 21:01:40 EDT 2024
Fri Oct 25 23:48:47 EDT 2024
Thu Nov 21 23:30:55 EST 2024
Sat Sep 28 08:38:17 EDT 2024
Thu May 30 08:52:59 EDT 2019
Wed Nov 11 00:30:11 EST 2020
Tue Dec 10 23:06:09 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c455t-ab6320a15e54faeabe4c1519a987bcd75d76e84e71d360bc58e3e6c645f50a423
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://doi.org/10.1073/pnas.76.3.1018
PMID 286290
PQID 74500299
PQPubID 23479
PageCount 4
ParticipantIDs proquest_miscellaneous_74500299
pubmedcentral_primary_oai_pubmedcentral_nih_gov_383178
pnas_primary_76_3_1018
crossref_primary_10_1073_pnas_76_3_1018
jstor_primary_69212
pubmed_primary_286290
pnas_primary_76_3_1018_fulltext
ProviderPackageCode RNA
PNE
PublicationCentury 1900
PublicationDate 19790301
PublicationDateYYYYMMDD 1979-03-01
PublicationDate_xml – month: 3
  year: 1979
  text: 19790301
  day: 1
PublicationDecade 1970
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Proceedings of the National Academy of Sciences - PNAS
PublicationTitleAlternate Proc Natl Acad Sci U S A
PublicationYear 1979
Publisher National Academy of Sciences of the United States of America
National Acad Sciences
Publisher_xml – sequence: 0
  name: National Academy of Sciences of the United States of America
– name: National Acad Sciences
SSID ssj0009580
Score 1.2873943
Snippet The ability of polynucleotides or polynucleotide duplexes such as poly(I)· poly(C) to induce interferon production is proposed to depend on the existence of...
The ability of polynucleotides or polynucleotide duplexes such as poly(I).poly(C) to induce interferon production is proposed to depend on the existence of...
SourceID pubmedcentral
proquest
crossref
pubmed
pnas
jstor
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1018
SubjectTerms Adenosine
Calorimetry
Coordinate systems
DNA
Glycosides
Inosine
Interferon Inducers
Interferons
Nucleic Acid Conformation
Nucleic acids
Nucleosides
Nucleotides
Poly I-C
Polynucleotides
Purine nucleosides
Purines
Rotation
Title Interferon Induction: A Conformational Hypothesis
URI https://www.jstor.org/stable/69212
http://www.pnas.org/content/76/3/1018.abstract
https://www.ncbi.nlm.nih.gov/pubmed/286290
https://search.proquest.com/docview/74500299
https://pubmed.ncbi.nlm.nih.gov/PMC383178
Volume 76
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB0VxIEL6i6ghraQA1LpIbvr9Te3CoEQElUPIHGLbMcRK4F3RZZD_33HcRItiFOv8cSJPLbfTPzmBeCUUFJ5ZauCV5iiMGdEoTWrCsUQfLQS0rNYjXz7W1zfs5sH_tAVhTUdrTI4u5iEp-dJWDy23MrVs5v2PLHpn9sLzKqIVNMt2EL07TP0QWhXpbKTOe6-bM56oUZJp6tgmokUExpTVrULO3MM5-NmvIFIiZQYlU7R-KOo8z15cgONrj7DXhdG5r_S647gkw9jGHULtcnPOjXpn_tA2m9-tX9Zhhzz7yQWe56bHBPhoXIRu3r8u4rFWM2iOYD7q8u7i-ui-09C4Rjn68JYQeczQ7jnrDbeWM8cArk2WknrKoluEF4xL0lFxcw6rjz1wgnGaz4zGE8dwnZYBv8FcmsZBkjGRmRnnNTKYTpG0c2icrQiNIMf_ViVqySHUbbH2JKWccRKKUoaaWMqg3E7lIOZ0IiSGRy2Zv3FDfOTjxvKuiPBRIvOGSUugXiuYYJfvuIzGY-HizqDg-SaoZfk4AzEG5cNzVFa-20LzrhWYjvNsKP_vfEr7BItdeKqfYPt9cur_47By9oeR-jgx-2c_QeONu-8
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB21UKlcqkJBTWkhh0ptD9ldr7-5IVS0bVnUA0jcIttxxErFuyLLof-ecZxES8Wp13jiRB7bMy9-8wLwmVBSeWWrglcIUZgzotCaVYViGHy0EtKzWI08vxSza_bzht90RWFNR6sMzi5G4c_dKCxuW27l6s6Ne57Y-Pf8DFEVkWr8ErY5lZr0GH2Q2lWp8GSK-y-bsl6qUdLxKphmJMWIRtCqduDVFBP6uB1vxKRES4xap2j8XN75L31yIx6dv4U3XSKZn6YX3oUXPuzBbrdUm_xrpyf97R2Q9qtf7e-XIUcEnuRiT3KTIxQeahexq9u_q1iO1Syafbg-_351Niu6PyUUjnG-LowVdDoxhHvOauON9cxhKNdGK2ldJdERwivmJamomFjHladeOMF4zScGM6oD2ArL4N9Dbi3DFMnYGNsZJ7VyCMgoOlpUjlaEZvClH6tylQQxyvYgW9IyjlgpRUkjcUxlsNcO5WAmNMbJDA5as_7ihvnx8w1l3dFgokXnjBIXQTzZMMEvH_CZjMfjRZ3BfnLN0EtycAbiicuG5iiu_bQF51wrsp3m2If_vfEYXs-u5hflxY_LX4ewQ7TUibn2EbbW9w_-E6Yya3vUztxHqhfyKw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5RWlVcqkJBpC9yqNT2kM16_e6tol3RB4hDkbhFfkWsVLIRuxz494zjJFoqTr3GEyeaGXtm4m--AHwglPigrC-4xxKFOSMKrZkvFMPgo5WQgcVu5NMzcXLBfl7yyy1QQy9MB9p3djFp_l5PmsVVh61sr1054MTK89NjrKqIVGXr6_IJPOUUfWyo00e6XZWaT2a4B7MZG-gaJS3bxqwmUkxoLFzVDjybYVIft-SNuJSgiZHvFIUfyz3_hVBuxKT5S3jRJ5P51_TSu7AVmj3Y7ZfrKv_Uc0p_fgWk-_JXh5tlk2MVnihjv-Qmx3J47F_Eqa7u2tiStVqs9uFi_v3P8UnR_y2hcIzzdWGsoLOpITxwVptgbGAOw7k2WknrvERjiKBYkMRTMbWOq0CDcILxmk8NZlUHsN0sm3AIubUM0yRjY3xnnNTKYVFG0djCO-oJzeDjoKuqTaQYVXeYLWkVNVZJUdEIHlMZ7HWqHMWExliZwUEnNlzcED96fKCqeyhMlOiNUeFCiKcbpgnLW3wm4_GIUWewn0wzzpIMnIF4YLJxOBJsPxxBv-uItpOfvf7fG4_g-fm3efX7x9mvN7BDtNQJvPYWttc3t-EdZjNr-75z3HsriPM-
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interferon+induction%3A+a+conformational+hypothesis&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Miles%2C+D+L&rft.au=Miles%2C+D+W&rft.au=Eyring%2C+H&rft.date=1979-03-01&rft.issn=0027-8424&rft.eissn=1091-6490&rft.volume=76&rft.issue=3&rft.spage=1018&rft.epage=1021&rft_id=info:doi/10.1073%2Fpnas.76.3.1018&rft.externalDBID=n%2Fa&rft.externalDocID=10_1073_pnas_76_3_1018
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F76%2F3.cover.gif
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F76%2F3.cover.gif