Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner

• Published in: International Journal of Obesity Vol. 42; no. 2; pp. 244 - 251
• Main Authors: Park, J H, Yoo, Y, Cho, M, Lim, J, Lindroth, A M, Park, Y J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2018; Nature Publishing Group
• Subjects: 38/22; 38/90; 631/337/176/1988; 631/443/319/1557; 631/443/319/1642/393; 631/80/642/1463; 631/80/86/2366; 692/699/1702/393; 692/699/2743/2815; 82; 82/1; 96/1; Animals; Animals, Newborn; Biochemical genetics; Body weight; Cellular Reprogramming - physiology; Deoxyribonucleic acid; Diet; Diet, High-Fat - adverse effects; Disease Models, Animal; DNA; DNA Methylation; Endoplasmic reticulum; Endoplasmic Reticulum Stress - genetics; Endoplasmic Reticulum Stress - physiology; Energy Metabolism - genetics; Energy Metabolism - physiology; Epidemiology; Epigenetic inheritance; Female; Females; Gene expression; Gene Expression Regulation; Genetic aspects; Germ cells; Gluconeogenesis; Glucose; Glucose transporter; Glycolysis; Health aspects; Health Promotion and Disease Prevention; High fat diet; Homeostasis; Hyperglycemia; Insulin; Insulin Resistance - genetics; Insulin Resistance - physiology; Internal Medicine; Liver; Loci; Male; Males; Medical research; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Metabolic Networks and Pathways; Metabolic regulation; Metabolism; Mice; Mice, Inbred Strains; Molecular modelling; Obesity; Obesity - genetics; Obesity - metabolism; Obesity - physiopathology; Offspring; Organs; original-article; Overweight; Progeny; Public Health; Rodents; Sex; Sex Characteristics; Signaling; Stresses; Transcription

Background/Objectives: Exposure to metabolic stress has been suggested to influence the susceptibility to metabolic disorders in offspring according to epidemiological and animal studies. Nevertheless, molecular mechanisms remain unclear. We investigated impacts of diet-induced paternal obesity on m...