Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood - Daskalakis, Nikolaos P.; Iatrou, Artemis; Chatzinakos, Chris; Jajoo, Aarti; Snijders, Clara; Wylie, Dennis; DiPietro, Christopher P.; Tsatsani, Ioulia; Chen, Chia-Yen; Pernia, Cameron D.; Soliva-Estruch, Marina; Arasappan, Dhivya; et al. (Science (American Association for the Advancement of Science), 2024)
Keywords: Amygdala; Amygdala - metabolism; Biomarkers; Biomarkers - metabolism; Blood; Blood plasma; Brain; Brain - metabolism; Brain mapping; Children; Chromosome Mapping; Dentate gyrus; Depressive Disorder, Major - genetics; DNA methylation; Epigenetics; Exons; Female; Gene expression; Gene mapping; Gene Regulatory Networks; Gene sequencing; Genes; Genetic Loci; Genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Health risk assessment; Hippocampus; Humans; Life span; Male; Mental depression; Mental disorders; Network analysis; Neurons - metabolism; Nuclei (cytology); Post traumatic stress disorder; Posttraumatic Stress Disorder; Prefrontal cortex; Prefrontal Cortex - metabolism; Proteins; Proteomics; Psychological stress; Risk; Sex differences; Signal transduction; Single-Cell Gene Expression Analysis; snRNA; Stat3 protein; Stress Disorders, Post-Traumatic - genetics; Suicide; Systems Biology; Transcription factors; Transcriptomics