Syringic and ascorbic acids prevent NDMA-induced pulmonary fibrogenesis, inflammation, apoptosis, and oxidative stress through the regulation of PI3K-Akt/PKB-mTOR-PTEN signaling pathway

• Published in: Metabolism open Vol. 14; p. 100179
• Main Authors: Somade, Oluwatobi T., Adeyi, Olubisi E., Ajayi, Babajide O., Asunde, Osiro O., Iloh, Precious D., Adesanya, Adedayo A., Babalola, Olanrewaju I., Folorunsho, Oluwaseyi T., Olakunle, Deborah A., Lawal, Opeyemi F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2022; Elsevier
• Subjects: Ascorbic acid; Fibrosis; Lung; N-Nitrosodimethylamine; Original Research Paper; Signaling; Syringic acid; Signaling; Ascorbic acid; N-Nitrosodimethylamine; Syringic acid; Lung; Fibrosis

Idiopathic lung fibrosis (ILF) is a severe and life threatening lung disorder that is characterized by scarring of lung tissue, leading to thickening and stiffening of affected areas. This study looked at the role played by PI3K-Akt/PKB-mToR signaling pathway in the pathogenesis of N-Nitrosodimethyl...