Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats

• Published in: Biochemistry and biophysics reports Vol. 33; p. 101428
• Main Authors: Adeyi, Olubisi E., Somade, Oluwatobi T., Ajayi, Babajide O., James, Adewale S., Adeyi, Akindele O., Olayemi, Zainab M., Tella, Nafisat B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2023; Elsevier
• Subjects: Dimethyl nitrosamine; Inflammation; Liver injury; Oxidative stress; Syringic acid; Dimethyl nitrosamine; Oxidative stress; Inflammation; Syringic acid; Liver injury

Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats. Following DMN administrations, malondialdehyde (MDA), nitric...