Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype

• Published in: Kidney international reports Vol. 8; no. 1; pp. 164 - 178
• Main Authors: Yoshida, Teruhiko, Latt, Khun Zaw, Rosenberg, Avi Z., Shrivastav, Shashi, Heymann, Jurgen, Halushka, Marc K., Winkler, Cheryl A., Kopp, Jeffrey B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023; Elsevier
• Subjects: APOL1; differentiation; miRNA; podocytes; RNA-seq; Translational Research; tRNA fragments; miRNA; differentiation; RNA-seq; tRNA fragments; APOL1; podocytes

The mechanisms in podocytes that mediate the pathologic effects of the APOL1 high-risk (HR) variants remain incompletely understood, although various molecular and cellular mechanisms have been proposed. We previously established conditionally immortalized human urine-derived podocyte-like epithelia...