Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells

• Published in: Pharmacological research Vol. 119; pp. 242 - 250
• Main Authors: Massaro, R.R., Faião-Flores, F., Rebecca, V.W., Sandri, S., Alves-Fernandes, D.K., Pennacchi, P.C., Smalley, K.S.M., Maria-Engler, S.S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2017
• Subjects: 2-methoxyestradiol; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Cell Cycle; Cell Cycle Checkpoints - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Chemoresistance; Estradiol - analogs & derivatives; Estradiol - pharmacology; Estrogen; Humans; Melanoma; Melanoma - drug therapy; Melanoma - pathology; Neoplasm Invasiveness - pathology; Neoplasm Invasiveness - prevention & control; Skin - drug effects; Skin - pathology; Skin Neoplasms - drug therapy; Skin Neoplasms - pathology; Melanoma; 2-methoxyestradiol; Estrogen; Chemoresistance

[Display omitted] Despite the recent advances in the clinical management of melanoma, there remains a need for new pharmacological approaches to treat this cancer. 2-methoxyestradiol (2ME) is a metabolite of estrogen that has shown anti-tumor effects in many cancer types. In this study we show that...