Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling

• Published in: Endocrine reviews Vol. 36; no. 4; pp. 357 - 384
• Main Authors: Pihlajamaa, Päivi, Sahu, Biswajyoti, Jänne, Olli A.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.08.2015
• Subjects: Androgen Antagonists; Androgen receptors; Androgens; Androgens - physiology; Cells, Cultured; Chromatin; Chromatin - metabolism; Dihydrotestosterone; Dihydrotestosterone - metabolism; DNA - metabolism; Gene regulation; Humans; Licensing; Male; Nucleotide sequence; Organ Specificity; Physiological effects; Physiology; Progestins; Prostate cancer; Prostatic Neoplasms; Proteins; Receptors; Receptors, Androgen - drug effects; Receptors, Androgen - genetics; Receptors, Androgen - physiology; Receptors, Glucocorticoid - physiology; Regulatory sequences; Response Elements; Signal Transduction - physiology; Steroid hormone receptors; Steroids; Testosterone; Testosterone - physiology; Tissues; Tumor cell lines

The physiological androgens testosterone and 5α-dihydrotestosterone regulate the development and maintenance of primary and secondary male sexual characteristics through binding to the androgen receptor (AR), a ligand-dependent transcription factor. In addition, a number of nonreproductive tissues o...