Time-Dependent Detrimental Effects of Distal Embolization on Myocardium and Microvasculature During Primary Percutaneous Coronary Intervention

• Published in: JACC. Cardiovascular interventions Vol. 5; no. 11; pp. 1170 - 1177
• Main Authors: Napodano, Massimo, MD, Peluso, Diletta, MD, Marra, Martina Perazzolo, MD, Frigo, Anna Chiara, MSc, Tarantini, Giuseppe, MD, PhD, Buja, Paolo, MD, PhD, Gasparetto, Valeria, MD, Fraccaro, Chiara, MD, Isabella, Giambattista, MD, Razzolini, Renato, MD, Iliceto, Sabino, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2012
• Subjects: Aged; Cardiomyopathies - etiology; Cardiovascular; distal embolization; Embolism - complications; Female; Humans; Intraoperative Complications - etiology; Male; Microvessels; Middle Aged; myocardial damage; myocardial infarction; Myocardial Infarction - surgery; Myocardium - pathology; Necrosis - etiology; Percutaneous Coronary Intervention; primary percutaneous coronary intervention; Prospective Studies; Time Factors; Vascular Diseases - etiology; DE; contrast-enhanced cardiac magnetic resonance; p-PCI; PMD; myocardial infarction; primary percutaneous coronary intervention; myocardial damage; persistent microvascular damage; CE-CMR; LGE; infarct-related artery; infarct size index; distal embolization; TIMI; STEMI; IRA; Thrombolysis in Myocardial Infarction; late gadolinium enhancement; ST-segment elevation myocardial infarction; ISI

Objectives The authors sought to investigate the impact of distal embolization (DE) on myocardial damage and microvascular reperfusion, according to time-to-treatment, using contrast-enhanced cardiac magnetic resonance (CE-CMR). Background DE, occurring during primary percutaneous coronary intervent...