An Inconvenient Truth: Calcium Sensors Are Calcium Buffers

• Published in: Trends in neurosciences (Regular ed.) Vol. 41; no. 12; pp. 880 - 884
• Main Authors: McMahon, Shane M., Jackson, Meyer B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2018
• Subjects: Animals; Brain - physiology; Buffers; Calcium - analysis; Calcium - chemistry; calcium imaging; calcium sensors; Calcium Signaling - physiology; in vivo imaging; Neurons - physiology; Optical Imaging; two-photon microscopy; two-photon microscopy; in vivo imaging; calcium sensors; calcium imaging

Recent advances in Ca2+ imaging have given neuroscientists a tool to follow the activity of large numbers of individual neurons simultaneously in vivo in the brains of animals as they are presented with sensory stimulation, respond to environmental challenges, and engage in behaviors. The Ca2+ senso...