Effect of Co-culturing both placenta-derived mesenchymal stem cells and their condition medium in the cancer cell (HepG2) migration, damage through apoptosis and cell cycle arrest

• Published in: Saudi journal of biological sciences Vol. 30; no. 2; p. 103519
• Main Authors: Opo, F.A. Dain Md, Moulay, Mohammed, Alrefaei, Ghadeer I., Alsubhi, Nouf H., Alkarim, Saleh, Rahman, Mohammed M.
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.02.2023; Elsevier
• Subjects: Apoptosis; Conditioned medium; Differentiation; HepG2; hPMSCs; Morphology; Original; IL; Conditioned medium; TBST; HCC; AFP; 30H; PVDF; 50H; 70H; hP-MSCs; 30P; 50P; Morphology; 70P; HepG2; Differentiation; hPMSCs; Apoptosis; IL, Interleukin; PVDF, Polyvinylidene Fluoride; TBST, Tris-Buffered Saline with 0.1% Tween 20 detergent; hP-MSCs, human Placenta derived Mesenchymal Stem Cells; 50P, 50% placenta; 30P, 30% placenta; AFP, Alfa Feto Protein; 30H, 30% HepG2; 70H, 70% HepG2; HCC, Hepatocellular Carcinoma; 50H, 50% HepG2; 70P, 70% placenta

Human placental-derived mesenchymal stem cells (hPMSCs) are a promising candidate to inhibit the proliferation of hepatocellular carcinoma (HCC) cell lines such as HepG2. The effects of hPMSCs and their conditioned media on HepG2 are, however, still a mystery. As a result, the goal of this study was...