SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production

• Published in: Science bulletin (Beijing) Vol. 66; no. 12; pp. 1194 - 1204
• Main Authors: Luo, Lingling, Li, Zhean, Zhao, Tiejun, Ju, Xiaohui, Ma, Peixiang, Jin, Boxing, Zhou, Yulin, He, Su, Huang, Jinhua, Xu, Xun, Zou, Yan, Li, Ping, Liang, Aibin, Liu, Jia, Chi, Tian, Huang, Xingxu, Ding, Qiang, Jin, Zhigang, Huang, Cheng, Zhang, Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.06.2021; Science China Press. Published by Elsevier B.V. and Science China Press
• Subjects: G3BP; Liquid-liquid phase separation; Nucleocapsid protein; SARS-CoV-2; Stress granules; Viral production; SARS-CoV-2; Viral production; Liquid-liquid phase separation; G3BP; Nucleocapsid protein; Stress granules; Liquid-Liquid Phase Separation; Nucleocapsid Protein; Stress Granules
• ISSN: 2095-9273; 2095-9281
• DOI: 10.1016/j.scib.2021.01.013

[Display omitted] A key to tackling the coronavirus disease 2019 (COVID-19) pandemic is to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host antiviral defense mechanisms. Stress granules (SGs), which are assembled during viral infection and function...