Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease

• Published in: Journal of advanced research Vol. 34; pp. 1 - 12
• Main Authors: Bian, Yaqi, Chen, Yan, Wang, Xiufen, Cui, Guozhen, Ung, Carolina Oi Lam, Lu, Jia-Hong, Cong, Weihong, Tang, Benqin, Lee, Simon Ming-Yuen
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier B.V 01.12.2021; Elsevier
• Subjects: Alzheimer Disease - drug therapy; Alzheimer’s disease; Amyloid beta proteins; Amyloid beta-Peptides - metabolism; Animals; Caproates; Cognition; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - etiology; Cresols; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2 - metabolism; Oxidative Stress; oxyphylla A; Proto-Oncogene Proteins c-akt; SAMP8; APP; NQO1; Oxidative stress; MWM; AD; Alzheimer’s disease; oxyphylla A; Amyloid beta proteins; HO-1; PHF; Aβ; NFTs; ARE; PD; SAMP8 mice; Nrf2; GSK3; AOE; ROS; SAMP8; Keap1; RLU; pRL-TK; ARE, antioxidant response element; ARE, antioxidant responsive element; PD, Parkinson’s disease; AD, Alzheimer’s disease; Aβ, amyloid beta; NFTs, neurofibrillary tangles; AOE, ethanolic extract of Alpinia oxyphylla; GSK3, glycogen synthase kinase 3; MWM, Morris Water Maze; Nrf2, erythroid-derived 2-related factor 2; NQO1, NAD(P)H:quinone oxidoreductase1; RLU, relative luciferase units; PHF, paired helical filaments; pRL-TK, Renilla luciferase reporter plasmid; ROS, reactive oxygen species; SAMP8 mice, senescence-accelerated mouse prone 8; Keap1, Keleh-like ECH-associated protein; HO-1, heme oxygenase-1; APP, amyloid precursor protein

[Display omitted] Alzheimer’s disease (AD) is a progressive brain disorder, and one of the most common causes of dementia and amnesia. Due to the complex pathogenesis of AD, the underlying mechanisms remain unclear. Although scientists have made increasing efforts to develop drugs for AD, no effecti...