The Transition from Gastric Intestinal Metaplasia to Gastric Cancer Involves POPDC1 and POPDC3 Downregulation

• Published in: International journal of molecular sciences Vol. 22; no. 10; p. 5359
• Main Authors: Gingold-Belfer, Rachel, Kessler-Icekson, Gania, Morgenstern, Sara, Rath-Wolfson, Lea, Zemel, Romy, Boltin, Doron, Levi, Zohar, Herman-Edelstein, Michal
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 19.05.2021; MDPI
• Subjects: Biomarkers; Biopsy; CDX2 protein; Cell cycle; Cell growth; Colon; Endoscopy; Gastric cancer; gastric intestinal metaplasia; Gastrointestinal surgery; Gene expression; Histology; Immunohistochemistry; Intestine; Medical prognosis; Membrane proteins; Metaplasia; Metastasis; Morphology; Mucin; Muscles; Patients; POPDC1 (BVES); POPDC3; Proteins; Stem cells; Transcription; Transcription factors; Tumor suppression; Tumorigenesis; Tumors

Intestinal metaplasia (IM) is an intermediate step in the progression from premalignant to malignant stages of gastric cancer (GC). The Popeye domain containing (POPDC) gene family encodes three transmembrane proteins, POPDC1, POPDC2, and POPDC3, initially described in muscles and later in epithelia...