Why does obesity cause diabetes?

• Published in: Cell metabolism Vol. 34; no. 1; pp. 11 - 20
• Main Authors: Klein, Samuel, Gastaldelli, Amalia, Yki-Järvinen, Hannele, Scherer, Philipp E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.01.2022
• Subjects: Adipose Tissue - metabolism; Adiposity; Diabetes Mellitus, Type 2 - metabolism; Humans; Insulin Resistance - physiology; Obesity - metabolism

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabet...