Evidence for Differences in the Sexual Transmission Efficiency of HIV Strains with Distinct Drug Resistance Genotypes

• Published in: Clinical infectious diseases Vol. 39; no. 8; pp. 1231 - 1238
• Main Authors: de Mendoza, Carmen, Rodriguez, Carmen, Corral, Angélica, del Romero, Jorge, Gallego, Oscar, Soriano, Vincent
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.10.2004; University of Chicago Press
• Subjects: Amino Acid Sequence; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretrovirals; Antiviral agents; Biological and medical sciences; Case-Control Studies; CD4 Lymphocyte Count; Drug resistance; Drug Resistance, Viral - genetics; Epidemiology. Vaccinations; Female; General aspects; Genetic mutation; Genotype; Genotypes; HIV; HIV 1; HIV Infections - transmission; HIV Protease - chemistry; HIV Protease - genetics; HIV Protease - metabolism; HIV Reverse Transcriptase - chemistry; HIV Reverse Transcriptase - genetics; HIV Reverse Transcriptase - metabolism; HIV-1 - classification; HIV-1 - drug effects; HIV-1 - genetics; HIV/AIDS; Human immunodeficiency virus 1; Human viral diseases; Humans; Infections; Infectious diseases; Male; Medical sciences; Mutation; Pharmacology. Drug treatments; Retrospective Studies; Risk Factors; RNA, Viral - blood; Sequence Alignment; Sequence Homology, Amino Acid; Sex Characteristics; Transmission efficiency; Transmitters; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viruses; Europe; Spain; HIV-1 virus; Transmission; Case control study; Efficiency; Antiviral; Nucleoside; Hospital; Failure; Human; Immunopathology; Treatment resistance; Typing; Retroviridae; Genotype; AIDS; Method; Immune deficiency; Lentivirus; Infection; Virus; Chemotherapy; Sexually transmitted disease; Treatment; Viral disease; Mutation; Human immunodeficiency virus; Comparative study

Background. The transmission of drug-resistant human immunodeficiency virus type 1 (HIV-1) is a matter of major concern, because it could compromise the response to antiretroviral therapy. Material and methods. From 1997 through 2003, genotypic drug resistance profiles in 89 patients with recent HIV...