Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

• Published in: Cell metabolism Vol. 30; no. 1; pp. 143 - 156.e5
• Main Authors: Ma, Xingzhe, Bi, Enguang, Lu, Yong, Su, Pan, Huang, Chunjian, Liu, Lintao, Wang, Qiang, Yang, Maojie, Kalady, Matthew F., Qian, Jianfei, Zhang, Aijun, Gupte, Anisha A., Hamilton, Dale J., Zheng, Chengyun, Yi, Qing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.07.2019
• Subjects: CD8+ T cells; cholesterol; exhaustion; immune checkpoints; tumor microenvironment; exhaustion; CD8+ T cells; cholesterol; tumor microenvironment; immune checkpoints

Tumor-infiltrating T cells often lose their effector function; however, the mechanisms are incompletely understood. We report that cholesterol in the tumor microenvironment induces CD8+ T cell expression of immune checkpoints and exhaustion. Tumor tissues enriched with cholesterol and cholesterol co...