Simultaneous quantification of niacin and its three main metabolites in human plasma by LC–MS/MS - Liu, Man; Zhang, Dan; Wang, Xiaolin; Zhang, Lina; Han, Jing; Yang, Man; Xiao, Xue; Zhang, Yanan; Liu, Huichen (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012)
Keywords: acetonitrile; Adult; Blanks; Calibration; centrifugation; Chromatography; Chromatography, Liquid - methods; Delayed-Action Preparations; Dosing; Drug Stability; Female; formic acid; Guidelines; Human; Humans; ionization; Linear Models; liquid chromatography; Male; Metabolites; Monitoring; N-methyl-2-pyridone-5-carboxamide; Niacin; Niacin - blood; Niacin - chemistry; Niacin - pharmacokinetics; Nicotinamide; Nicotinic Acids - blood; Nicotinic Acids - chemistry; Nicotinic Acids - pharmacokinetics; Nicotinuric acid; Pharmacokinetics; Pyridones - blood; Pyridones - chemistry; Pyridones - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; tandem mass spectrometry; Tandem Mass Spectrometry - methods; LLE; MRM; SPE; IS; N-methyl-2-pyridone-5-carboxamide; Niacin; Nicotinuric acid; CS; QC; NA; PPT; 2-Pyr; ESI; Nicotinamide; NAM; NUA; Pharmacokinetics; rLLOQ