Alzheimer's disease amyloid-β pathology in the lens of the eye

• Published in: Experimental eye research Vol. 221; p. 108974
• Main Authors: Moncaster, Juliet A., Moir, Robert D., Burton, Mark A., Chadwick, Oliver, Minaeva, Olga, Alvarez, Victor E., Ericsson, Maria, Clark, John I., McKee, Ann C., Tanzi, Rudolph E., Goldstein, Lee E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2022
• Subjects: Alzheimer Disease - genetics; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - metabolism; Amyloid precursor protein; Amyloid-β; Animals; Biomarker; Brain - pathology; Cataract; Cataract - pathology; Disease Models, Animal; Down syndrome; Genome-Wide Association Study; Humans; Lens; Mice; Mice, Transgenic; Neurodegenerative Diseases - pathology; Protein aggregation; Quasi-elastic light scattering; Transgenic mouse model; Quasi-elastic light scattering; APP; Biomarker; Cataract; Protein aggregation; Tg2576 Swedish mutation (APP-Swe); AD; GWAS; AH; FAD; SNC; Down syndrome; Amyloid precursor protein; Transgenic mouse model; DS; Aβ; MCI; QLS; Lens; Amyloid-β; Alzheimer's disease

Neuropathological hallmarks of Alzheimer's disease (AD) include pathogenic accumulation of amyloid-β (Aβ) peptides and age-dependent formation of amyloid plaques in the brain. AD-associated Aβ neuropathology begins decades before onset of cognitive symptoms and slowly progresses over the course...