Toxic metals and metalloids: Uptake, transport, detoxification, phytoremediation, and crop improvement for safer food

Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and...

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Published inMolecular plant Vol. 15; no. 1; pp. 27 - 44
Main Authors Zhao, Fang-Jie, Tang, Zhong, Song, Jia-Jun, Huang, Xin-Yuan, Wang, Peng
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 03.01.2022
Subjects
arsenic
Biodegradation, Environmental
Biological Transport - drug effects
cadmium
Crops, Agricultural - drug effects
Crops, Agricultural - genetics
Crops, Agricultural - growth & development
detoxification
Food Safety
genes
genetically modified organisms
germplasm
heavy metals
human health
hyperaccumulators
iron
lead
manganese
mercury
Metalloids - toxicity
Metals, Heavy - toxicity
methylation
phosphates
phytochelatins
phytoremediation
Plant Breeding - methods
quantitative traits
silicon
Soil - chemistry
Soil Pollutants - toxicity
toxic metals/metalloids
toxicity
transcription (genetics)
transporters
zinc
food safety
toxic metals/metalloids
phytoremediation
transporters
detoxification
heavy metals
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Abstract Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and their methylated species are taken up, translocated, and detoxified is prerequisite to developing strategies to limit their accumulation for safer food. Toxic metals are taken up and transported across different cellular compartments and plant tissues via various transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn), and iron (Fe) transporters. These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels. Complexation with thiol-rich compounds, such as phytochelatins, and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation. A number of genes involved in toxic metal uptake, transport, and detoxification have been identified, offering targets for genetic manipulation via gene editing or transgenic technologies. Natural variations in toxic metal accumulation exist within crop germplasm, and some of the quantitative trait loci underlying these variations have been cloned, paving the way for marker-assisted breeding of low metal accumulation crops. Using plants to extract and remove toxic metals from soil is also possible, but this phytoremediation approach requires metal hyperaccumulation for efficiency. Knowledge gaps and future research needs are also discussed. Accumulation of toxic metals and metalloids, such as arsenic, cadmium, lead, and mercury in food crops, can affect food safety and human health. This review discusses the molecular mechanisms and regulation of their uptake, transport, and detoxification as well as crop improvement strategies to reduce their accumulation in the edible parts. The potential of using metal-accumulating plants to clean up contaminated soil is also discussed.
AbstractList Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and their methylated species are taken up, translocated, and detoxified is prerequisite to developing strategies to limit their accumulation for safer food. Toxic metals are taken up and transported across different cellular compartments and plant tissues via various transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn), and iron (Fe) transporters. These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels. Complexation with thiol-rich compounds, such as phytochelatins, and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation. A number of genes involved in toxic metal uptake, transport, and detoxification have been identified, offering targets for genetic manipulation via gene editing or transgenic technologies. Natural variations in toxic metal accumulation exist within crop germplasm, and some of the quantitative trait loci underlying these variations have been cloned, paving the way for marker-assisted breeding of low metal accumulation crops. Using plants to extract and remove toxic metals from soil is also possible, but this phytoremediation approach requires metal hyperaccumulation for efficiency. Knowledge gaps and future research needs are also discussed.
Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and their methylated species are taken up, translocated, and detoxified is prerequisite to developing strategies to limit their accumulation for safer food. Toxic metals are taken up and transported across different cellular compartments and plant tissues via various transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn), and iron (Fe) transporters. These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels. Complexation with thiol-rich compounds, such as phytochelatins, and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation. A number of genes involved in toxic metal uptake, transport, and detoxification have been identified, offering targets for genetic manipulation via gene editing or transgenic technologies. Natural variations in toxic metal accumulation exist within crop germplasm, and some of the quantitative trait loci underlying these variations have been cloned, paving the way for marker-assisted breeding of low metal accumulation crops. Using plants to extract and remove toxic metals from soil is also possible, but this phytoremediation approach requires metal hyperaccumulation for efficiency. Knowledge gaps and future research needs are also discussed. Accumulation of toxic metals and metalloids, such as arsenic, cadmium, lead, and mercury in food crops, can affect food safety and human health. This review discusses the molecular mechanisms and regulation of their uptake, transport, and detoxification as well as crop improvement strategies to reduce their accumulation in the edible parts. The potential of using metal-accumulating plants to clean up contaminated soil is also discussed.
Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and their methylated species are taken up, translocated, and detoxified is prerequisite to developing strategies to limit their accumulation for safer food. Toxic metals are taken up and transported across different cellular compartments and plant tissues via various transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn), and iron (Fe) transporters. These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels. Complexation with thiol-rich compounds, such as phytochelatins, and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation. A number of genes involved in toxic metal uptake, transport, and detoxification have been identified, offering targets for genetic manipulation via gene editing or transgenic technologies. Natural variations in toxic metal accumulation exist within crop germplasm, and some of the quantitative trait loci underlying these variations have been cloned, paving the way for marker-assisted breeding of low metal accumulation crops. Using plants to extract and remove toxic metals from soil is also possible, but this phytoremediation approach requires metal hyperaccumulation for efficiency. Knowledge gaps and future research needs are also discussed.
Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and their methylated species are taken up, translocated, and detoxified is prerequisite to developing strategies to limit their accumulation for safer food. Toxic metals are taken up and transported across different cellular compartments and plant tissues via various transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn), and iron (Fe) transporters. These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels. Complexation with thiol-rich compounds, such as phytochelatins, and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation. A number of genes involved in toxic metal uptake, transport, and detoxification have been identified, offering targets for genetic manipulation via gene editing or transgenic technologies. Natural variations in toxic metal accumulation exist within crop germplasm, and some of the quantitative trait loci underlying these variations have been cloned, paving the way for marker-assisted breeding of low metal accumulation crops. Using plants to extract and remove toxic metals from soil is also possible, but this phytoremediation approach requires metal hyperaccumulation for efficiency. Knowledge gaps and future research needs are also discussed.Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) in food crops that poses significant risks to human health. Understanding how these toxic metals and their methylated species are taken up, translocated, and detoxified is prerequisite to developing strategies to limit their accumulation for safer food. Toxic metals are taken up and transported across different cellular compartments and plant tissues via various transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn), and iron (Fe) transporters. These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels. Complexation with thiol-rich compounds, such as phytochelatins, and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation. A number of genes involved in toxic metal uptake, transport, and detoxification have been identified, offering targets for genetic manipulation via gene editing or transgenic technologies. Natural variations in toxic metal accumulation exist within crop germplasm, and some of the quantitative trait loci underlying these variations have been cloned, paving the way for marker-assisted breeding of low metal accumulation crops. Using plants to extract and remove toxic metals from soil is also possible, but this phytoremediation approach requires metal hyperaccumulation for efficiency. Knowledge gaps and future research needs are also discussed.
Author Tang, Zhong
Wang, Peng
Zhao, Fang-Jie
Song, Jia-Jun
Huang, Xin-Yuan
Author_xml – sequence: 1
  givenname: Fang-Jie
  orcidid: 0000-0002-0164-169X
  surname: Zhao
  fullname: Zhao, Fang-Jie
  email: fangjie.zhao@njau.edu.cn
– sequence: 2
  givenname: Zhong
  surname: Tang
  fullname: Tang, Zhong
– sequence: 3
  givenname: Jia-Jun
  surname: Song
  fullname: Song, Jia-Jun
– sequence: 4
  givenname: Xin-Yuan
  surname: Huang
  fullname: Huang, Xin-Yuan
– sequence: 5
  givenname: Peng
  surname: Wang
  fullname: Wang, Peng
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34619329$$D View this record in MEDLINE/PubMed
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Keywords food safety
toxic metals/metalloids
phytoremediation
transporters
detoxification
heavy metals
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Snippet Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities, leading to excessive accumulation of arsenic (As),...
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SubjectTerms arsenic
Biodegradation, Environmental
Biological Transport - drug effects
cadmium
Crops, Agricultural - drug effects
Crops, Agricultural - genetics
Crops, Agricultural - growth & development
detoxification
Food Safety
genes
genetically modified organisms
germplasm
heavy metals
human health
hyperaccumulators
iron
lead
manganese
mercury
Metalloids - toxicity
Metals, Heavy - toxicity
methylation
phosphates
phytochelatins
phytoremediation
Plant Breeding - methods
quantitative traits
silicon
Soil - chemistry
Soil Pollutants - toxicity
toxic metals/metalloids
toxicity
transcription (genetics)
transporters
zinc
Title Toxic metals and metalloids: Uptake, transport, detoxification, phytoremediation, and crop improvement for safer food
URI https://dx.doi.org/10.1016/j.molp.2021.09.016
https://www.ncbi.nlm.nih.gov/pubmed/34619329
https://www.proquest.com/docview/2580696411
https://www.proquest.com/docview/2636698523
Volume 15
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