Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway

• Published in: Biochemical and biophysical research communications Vol. 509; no. 2; pp. 395 - 401
• Main Authors: Xue, Ye, He, Jie-Tao, Zhang, Kai-Kai, Chen, Li-Jian, Wang, Qi, Xie, Xiao-Li
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.02.2019
• Subjects: actin; Blood-brain barrier; caudal vein; endothelial cells; hippocampus; males; metalloproteinases; METH; methamphetamines; microfilaments; myosin light chains; neurotoxicity; permeability; phosphorylation; rats; RhoA/ROCK pathway; Tight junction; tight junctions; METH; Tight junction; RhoA/ROCK pathway; Blood-brain barrier

Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 inje...