Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway
Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 inje...
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| Published in | Biochemical and biophysical research communications Vol. 509; no. 2; pp. 395 - 401 |
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| Format | Journal Article |
| Language | English |
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05.02.2019
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| Abstract | Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 injections (i.p.) at 12-h intervals and sacrificed 24 h after the last METH injection. To evaluate BBB permeability, 6 rats were administered with Evans blue (EB) by tail vein injection 1 h prior to sacrifice. EB levels significantly increased in both left and right frontal lobes in METH-treated rats, suggesting increase of BBB permeability, which was proved by the rearrangement of F-actin cytoskeleton and decreased expressions of tight junction (TJ) proteins in hippocampus. Over-expressions of RhoA, ROCK, myosin light chain (MLC), cofilin, phosphorylation (p)-MLC, p-cofilin and matrix metalloproteinase (MMP)-9 were observed, indicating activated RhoA/ROCK pathway. Rat brain microvascular endothelial cells (RBMECs) were isolated and treated with inhibitors of RhoA and ROCK followed by METH. Pretreatments of the inhibitors significantly decreased expressions of RhoA, ROCK, MLC, cofilin, p-MLC and p-cofilin, increased expressions of TJ proteins, suppressed F-actin cytoskeleton rearrangement and reduced the permeability of RBMECs. These results suggested that METH increased BBB permeability through activating the RhoA/ROCK pathway, which resulted in F-actin cytoskeleton rearrangement and down-regulation of TJ proteins.
•METH increased blood brain barrier (BBB) permeability.•METH rearranged F-actin cytoskeleton and decreased tight junction (TJ) proteins.•METH activated RhoA/ROCK pathway.•Inhibition of this pathway decreased F-actin rearrangement and increased TJ proteins.•Inhibition of RhoA/ROCK pathway decreased METH-induced increase of BBB permeability. |
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| AbstractList | Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 injections (i.p.) at 12-h intervals and sacrificed 24 h after the last METH injection. To evaluate BBB permeability, 6 rats were administered with Evans blue (EB) by tail vein injection 1 h prior to sacrifice. EB levels significantly increased in both left and right frontal lobes in METH-treated rats, suggesting increase of BBB permeability, which was proved by the rearrangement of F-actin cytoskeleton and decreased expressions of tight junction (TJ) proteins in hippocampus. Over-expressions of RhoA, ROCK, myosin light chain (MLC), cofilin, phosphorylation (p)-MLC, p-cofilin and matrix metalloproteinase (MMP)-9 were observed, indicating activated RhoA/ROCK pathway. Rat brain microvascular endothelial cells (RBMECs) were isolated and treated with inhibitors of RhoA and ROCK followed by METH. Pretreatments of the inhibitors significantly decreased expressions of RhoA, ROCK, MLC, cofilin, p-MLC and p-cofilin, increased expressions of TJ proteins, suppressed F-actin cytoskeleton rearrangement and reduced the permeability of RBMECs. These results suggested that METH increased BBB permeability through activating the RhoA/ROCK pathway, which resulted in F-actin cytoskeleton rearrangement and down-regulation of TJ proteins. Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 injections (i.p.) at 12-h intervals and sacrificed 24 h after the last METH injection. To evaluate BBB permeability, 6 rats were administered with Evans blue (EB) by tail vein injection 1 h prior to sacrifice. EB levels significantly increased in both left and right frontal lobes in METH-treated rats, suggesting increase of BBB permeability, which was proved by the rearrangement of F-actin cytoskeleton and decreased expressions of tight junction (TJ) proteins in hippocampus. Over-expressions of RhoA, ROCK, myosin light chain (MLC), cofilin, phosphorylation (p)-MLC, p-cofilin and matrix metalloproteinase (MMP)-9 were observed, indicating activated RhoA/ROCK pathway. Rat brain microvascular endothelial cells (RBMECs) were isolated and treated with inhibitors of RhoA and ROCK followed by METH. Pretreatments of the inhibitors significantly decreased expressions of RhoA, ROCK, MLC, cofilin, p-MLC and p-cofilin, increased expressions of TJ proteins, suppressed F-actin cytoskeleton rearrangement and reduced the permeability of RBMECs. These results suggested that METH increased BBB permeability through activating the RhoA/ROCK pathway, which resulted in F-actin cytoskeleton rearrangement and down-regulation of TJ proteins.Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 injections (i.p.) at 12-h intervals and sacrificed 24 h after the last METH injection. To evaluate BBB permeability, 6 rats were administered with Evans blue (EB) by tail vein injection 1 h prior to sacrifice. EB levels significantly increased in both left and right frontal lobes in METH-treated rats, suggesting increase of BBB permeability, which was proved by the rearrangement of F-actin cytoskeleton and decreased expressions of tight junction (TJ) proteins in hippocampus. Over-expressions of RhoA, ROCK, myosin light chain (MLC), cofilin, phosphorylation (p)-MLC, p-cofilin and matrix metalloproteinase (MMP)-9 were observed, indicating activated RhoA/ROCK pathway. Rat brain microvascular endothelial cells (RBMECs) were isolated and treated with inhibitors of RhoA and ROCK followed by METH. Pretreatments of the inhibitors significantly decreased expressions of RhoA, ROCK, MLC, cofilin, p-MLC and p-cofilin, increased expressions of TJ proteins, suppressed F-actin cytoskeleton rearrangement and reduced the permeability of RBMECs. These results suggested that METH increased BBB permeability through activating the RhoA/ROCK pathway, which resulted in F-actin cytoskeleton rearrangement and down-regulation of TJ proteins. Methamphetamine (METH) is a psychostimulant with severe neurotoxicity, which is related to an increase of blood-brain barrier (BBB) permeability. However, the exact mechanisms have not been fully illuminated. In the present study, male Sprague Dawley rats were treated with METH or saline with 8 injections (i.p.) at 12-h intervals and sacrificed 24 h after the last METH injection. To evaluate BBB permeability, 6 rats were administered with Evans blue (EB) by tail vein injection 1 h prior to sacrifice. EB levels significantly increased in both left and right frontal lobes in METH-treated rats, suggesting increase of BBB permeability, which was proved by the rearrangement of F-actin cytoskeleton and decreased expressions of tight junction (TJ) proteins in hippocampus. Over-expressions of RhoA, ROCK, myosin light chain (MLC), cofilin, phosphorylation (p)-MLC, p-cofilin and matrix metalloproteinase (MMP)-9 were observed, indicating activated RhoA/ROCK pathway. Rat brain microvascular endothelial cells (RBMECs) were isolated and treated with inhibitors of RhoA and ROCK followed by METH. Pretreatments of the inhibitors significantly decreased expressions of RhoA, ROCK, MLC, cofilin, p-MLC and p-cofilin, increased expressions of TJ proteins, suppressed F-actin cytoskeleton rearrangement and reduced the permeability of RBMECs. These results suggested that METH increased BBB permeability through activating the RhoA/ROCK pathway, which resulted in F-actin cytoskeleton rearrangement and down-regulation of TJ proteins. •METH increased blood brain barrier (BBB) permeability.•METH rearranged F-actin cytoskeleton and decreased tight junction (TJ) proteins.•METH activated RhoA/ROCK pathway.•Inhibition of this pathway decreased F-actin rearrangement and increased TJ proteins.•Inhibition of RhoA/ROCK pathway decreased METH-induced increase of BBB permeability. |
| Author | Wang, Qi Xie, Xiao-Li Chen, Li-Jian He, Jie-Tao Zhang, Kai-Kai Xue, Ye |
| Author_xml | – sequence: 1 givenname: Ye surname: Xue fullname: Xue, Ye organization: Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China – sequence: 2 givenname: Jie-Tao surname: He fullname: He, Jie-Tao organization: Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China – sequence: 3 givenname: Kai-Kai surname: Zhang fullname: Zhang, Kai-Kai organization: Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China – sequence: 4 givenname: Li-Jian surname: Chen fullname: Chen, Li-Jian organization: Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China – sequence: 5 givenname: Qi orcidid: 0000-0002-1556-2167 surname: Wang fullname: Wang, Qi email: wangqi_legmed@vip.163.com, wangqi_legmed@126.com organization: Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China – sequence: 6 givenname: Xiao-Li surname: Xie fullname: Xie, Xiao-Li email: xiexiaoli1999@126.com organization: Department of Toxicology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China |
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| Cites_doi | 10.1007/s11481-008-9121-7 10.1124/pr.57.2.4 10.3390/ijms12021222 10.1016/j.drugalcdep.2012.11.016 10.1074/jbc.273.45.29745 10.1093/toxsci/kfx264 10.1016/j.neuropharm.2013.08.004 10.1096/fj.13-234203 10.1523/JNEUROSCI.6409-11.2012 10.1016/j.taap.2018.04.037 10.1074/jbc.274.49.35179 10.1053/j.gastro.2006.08.022 10.1096/fj.07-8329com 10.2353/ajpath.2010.100168 10.1212/WNL.0b013e3182697e70 10.1042/BST20120103 10.1371/journal.pone.0079954 10.1111/febs.13412 10.1093/cvr/cvq086 10.1160/TH09-06-0403 |
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| Keywords | METH Tight junction RhoA/ROCK pathway Blood-brain barrier |
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| References | Spindler, Schlegel, Waschke (bib16) 2010; 87 Khatri, McKinney, Swenson, Janardhan (bib23) 2012; 79 Fanning, Jameson, Jesaitis, Anderson (bib7) 1998; 273 Panenka, Procyshyn, Lecomte, MacEwan, Flynn, Honer, Barr (bib3) 2013; 129 Schreibelt, Kooij, Reijerkerk, van Doorn, Gringhuis, van der Pol, Weksler, Romero, Couraud, Piontek, Blasig, Dijkstra, Ronken, de Vries (bib18) 2007; 21 Zhou, Huang, Li, Huang, Tang, Kwan, Hoi, Lee (bib14) 2018; 350 Liu, Li, Wu, Ding (bib21) 2011; 12 Kushwaha, Mishra, Tripathi, Raza, Mandrah, Roy, Bandyopadhyay (bib9) 2018; 162 Shiobara, Usui, Han, Isoda, Nagumo (bib13) 2013; 8 Wang, Schwarz, Graham, Wang, Su, Clayburgh, Abraham, Turner (bib12) 2006; 131 Liu, Jin, Liu, Liu (bib22) 2012; 32 Halpin, Northrop, Yamamoto (bib1) 2014; vol. 39 Hall (bib10) 2012; 40 Gu, Xue, Wang, Wang, Chen, ShangGuan, Lian, Zhong, Meng (bib20) 2013; 75 Hawkins, Davis (bib5) 2005; 57 Ivanov, Parkos, Nusrat (bib11) 2010; 177 Tsukita, Furuse, Itoh (bib6) 2001; 2 Keaney, Campbell (bib4) 2015; 282 Abdul Muneer, Alikunju, Szlachetka, Murrin, Haorah (bib8) 2011; 6 Le Drean, Haure-Mirande, Ferrier, Bonnet, Hulin, de Coppet, Segain (bib19) 2014; 28 Wittchen, Haskins, Stevenson (bib17) 1999; 274 Yamamoto, Raudensky (bib2) 2008; 3 Beckers, van Hinsbergh, van Nieuw Amerongen (bib15) 2010; 103 Abdul Muneer (10.1016/j.bbrc.2018.12.144_bib8) 2011; 6 Panenka (10.1016/j.bbrc.2018.12.144_bib3) 2013; 129 Wittchen (10.1016/j.bbrc.2018.12.144_bib17) 1999; 274 Keaney (10.1016/j.bbrc.2018.12.144_bib4) 2015; 282 Wang (10.1016/j.bbrc.2018.12.144_bib12) 2006; 131 Shiobara (10.1016/j.bbrc.2018.12.144_bib13) 2013; 8 Yamamoto (10.1016/j.bbrc.2018.12.144_bib2) 2008; 3 Hawkins (10.1016/j.bbrc.2018.12.144_bib5) 2005; 57 Khatri (10.1016/j.bbrc.2018.12.144_bib23) 2012; 79 Ivanov (10.1016/j.bbrc.2018.12.144_bib11) 2010; 177 Halpin (10.1016/j.bbrc.2018.12.144_bib1) 2014; vol. 39 Tsukita (10.1016/j.bbrc.2018.12.144_bib6) 2001; 2 Spindler (10.1016/j.bbrc.2018.12.144_bib16) 2010; 87 Liu (10.1016/j.bbrc.2018.12.144_bib22) 2012; 32 Zhou (10.1016/j.bbrc.2018.12.144_bib14) 2018; 350 Gu (10.1016/j.bbrc.2018.12.144_bib20) 2013; 75 Liu (10.1016/j.bbrc.2018.12.144_bib21) 2011; 12 Hall (10.1016/j.bbrc.2018.12.144_bib10) 2012; 40 Le Drean (10.1016/j.bbrc.2018.12.144_bib19) 2014; 28 Fanning (10.1016/j.bbrc.2018.12.144_bib7) 1998; 273 Schreibelt (10.1016/j.bbrc.2018.12.144_bib18) 2007; 21 Kushwaha (10.1016/j.bbrc.2018.12.144_bib9) 2018; 162 Beckers (10.1016/j.bbrc.2018.12.144_bib15) 2010; 103 |
| References_xml | – volume: 40 start-page: 1378 year: 2012 end-page: 1382 ident: bib10 article-title: Rho family GTPases publication-title: Biochem. Soc. Trans. – volume: 103 start-page: 40 year: 2010 end-page: 55 ident: bib15 article-title: Driving Rho GTPase activity in endothelial cells regulates barrier integrity publication-title: Thromb. Haemostasis – volume: 79 start-page: S52 year: 2012 end-page: S57 ident: bib23 article-title: Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke publication-title: Neurology – volume: 32 start-page: 3044 year: 2012 end-page: 3057 ident: bib22 article-title: Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage publication-title: J. Neurosci.: the official journal of the Society for Neuroscience – volume: 350 start-page: 32 year: 2018 end-page: 42 ident: bib14 article-title: Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish publication-title: Toxicol. Appl. Pharmacol. – volume: 87 start-page: 243 year: 2010 end-page: 253 ident: bib16 article-title: Role of GTPases in control of microvascular permeability publication-title: Cardiovasc. Res. – volume: 129 start-page: 167 year: 2013 end-page: 179 ident: bib3 article-title: Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings publication-title: Drug Alcohol Depend. – volume: 177 start-page: 512 year: 2010 end-page: 524 ident: bib11 article-title: Cytoskeletal regulation of epithelial barrier function during inflammation publication-title: Am. J. Pathol. – volume: 12 start-page: 1222 year: 2011 end-page: 1231 ident: bib21 article-title: Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats publication-title: Int. J. Mol. Sci. – volume: 131 start-page: 1153 year: 2006 end-page: 1163 ident: bib12 article-title: IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction publication-title: Gastroenterology – volume: 2 start-page: 285 year: 2001 end-page: 293 ident: bib6 article-title: Multifunctional strands in tight junctions, Nature reviews publication-title: Molecular cell biology – volume: 3 start-page: 203 year: 2008 end-page: 217 ident: bib2 article-title: The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse publication-title: J. Neuroimmune Pharmacol.: the official journal of the Society on NeuroImmune Pharmacology – volume: 273 start-page: 29745 year: 1998 end-page: 29753 ident: bib7 article-title: The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton publication-title: J. Biol. Chem. – volume: vol. 39 start-page: 1031 year: 2014 end-page: 1038 ident: bib1 publication-title: Ammonia Mediates Methamphetamine-induced Increases in Glutamate and Excitotoxicity, Neuropsychopharmacology – volume: 57 start-page: 173 year: 2005 end-page: 185 ident: bib5 article-title: The blood-brain barrier/neurovascular unit in health and disease publication-title: Pharmacol. Rev. – volume: 6 year: 2011 ident: bib8 article-title: Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction publication-title: Mol. Neurodegener. – volume: 8 year: 2013 ident: bib13 article-title: The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin publication-title: PLoS One – volume: 75 start-page: 407 year: 2013 end-page: 415 ident: bib20 article-title: Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway publication-title: Neuropharmacology – volume: 162 start-page: 406 year: 2018 end-page: 428 ident: bib9 article-title: Arsenic attenuates heparin-binding EGF-like growth factor/EGFR signaling that promotes matrix metalloprotease 9-dependent astrocyte damage in the developing rat brain publication-title: Toxicol. Sci.: an official journal of the Society of Toxicology – volume: 21 start-page: 3666 year: 2007 end-page: 3676 ident: bib18 article-title: Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling publication-title: Faseb. J.: official publication of the Federation of American Societies for Experimental Biology – volume: 28 start-page: 1059 year: 2014 end-page: 1070 ident: bib19 article-title: Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway publication-title: Faseb. J.: official publication of the Federation of American Societies for Experimental Biology – volume: 274 start-page: 35179 year: 1999 end-page: 35185 ident: bib17 article-title: Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3 publication-title: J. Biol. Chem. – volume: 282 start-page: 4067 year: 2015 end-page: 4079 ident: bib4 article-title: The dynamic blood-brain barrier publication-title: FEBS J. – volume: 3 start-page: 203 year: 2008 ident: 10.1016/j.bbrc.2018.12.144_bib2 article-title: The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse publication-title: J. Neuroimmune Pharmacol.: the official journal of the Society on NeuroImmune Pharmacology doi: 10.1007/s11481-008-9121-7 – volume: 57 start-page: 173 year: 2005 ident: 10.1016/j.bbrc.2018.12.144_bib5 article-title: The blood-brain barrier/neurovascular unit in health and disease publication-title: Pharmacol. Rev. doi: 10.1124/pr.57.2.4 – volume: 12 start-page: 1222 year: 2011 ident: 10.1016/j.bbrc.2018.12.144_bib21 article-title: Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms12021222 – volume: 129 start-page: 167 year: 2013 ident: 10.1016/j.bbrc.2018.12.144_bib3 article-title: Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings publication-title: Drug Alcohol Depend. doi: 10.1016/j.drugalcdep.2012.11.016 – volume: 273 start-page: 29745 year: 1998 ident: 10.1016/j.bbrc.2018.12.144_bib7 article-title: The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.45.29745 – volume: vol. 39 start-page: 1031 year: 2014 ident: 10.1016/j.bbrc.2018.12.144_bib1 – volume: 162 start-page: 406 year: 2018 ident: 10.1016/j.bbrc.2018.12.144_bib9 article-title: Arsenic attenuates heparin-binding EGF-like growth factor/EGFR signaling that promotes matrix metalloprotease 9-dependent astrocyte damage in the developing rat brain publication-title: Toxicol. Sci.: an official journal of the Society of Toxicology doi: 10.1093/toxsci/kfx264 – volume: 75 start-page: 407 year: 2013 ident: 10.1016/j.bbrc.2018.12.144_bib20 article-title: Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.08.004 – volume: 28 start-page: 1059 year: 2014 ident: 10.1016/j.bbrc.2018.12.144_bib19 article-title: Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway publication-title: Faseb. J.: official publication of the Federation of American Societies for Experimental Biology doi: 10.1096/fj.13-234203 – volume: 2 start-page: 285 year: 2001 ident: 10.1016/j.bbrc.2018.12.144_bib6 article-title: Multifunctional strands in tight junctions, Nature reviews publication-title: Molecular cell biology – volume: 32 start-page: 3044 year: 2012 ident: 10.1016/j.bbrc.2018.12.144_bib22 article-title: Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage publication-title: J. Neurosci.: the official journal of the Society for Neuroscience doi: 10.1523/JNEUROSCI.6409-11.2012 – volume: 350 start-page: 32 year: 2018 ident: 10.1016/j.bbrc.2018.12.144_bib14 article-title: Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2018.04.037 – volume: 274 start-page: 35179 year: 1999 ident: 10.1016/j.bbrc.2018.12.144_bib17 article-title: Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.49.35179 – volume: 131 start-page: 1153 year: 2006 ident: 10.1016/j.bbrc.2018.12.144_bib12 article-title: IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.08.022 – volume: 21 start-page: 3666 year: 2007 ident: 10.1016/j.bbrc.2018.12.144_bib18 article-title: Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling publication-title: Faseb. J.: official publication of the Federation of American Societies for Experimental Biology doi: 10.1096/fj.07-8329com – volume: 177 start-page: 512 year: 2010 ident: 10.1016/j.bbrc.2018.12.144_bib11 article-title: Cytoskeletal regulation of epithelial barrier function during inflammation publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2010.100168 – volume: 79 start-page: S52 year: 2012 ident: 10.1016/j.bbrc.2018.12.144_bib23 article-title: Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke publication-title: Neurology doi: 10.1212/WNL.0b013e3182697e70 – volume: 6 year: 2011 ident: 10.1016/j.bbrc.2018.12.144_bib8 article-title: Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction publication-title: Mol. Neurodegener. – volume: 40 start-page: 1378 year: 2012 ident: 10.1016/j.bbrc.2018.12.144_bib10 article-title: Rho family GTPases publication-title: Biochem. Soc. Trans. doi: 10.1042/BST20120103 – volume: 8 year: 2013 ident: 10.1016/j.bbrc.2018.12.144_bib13 article-title: The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin publication-title: PLoS One doi: 10.1371/journal.pone.0079954 – volume: 282 start-page: 4067 year: 2015 ident: 10.1016/j.bbrc.2018.12.144_bib4 article-title: The dynamic blood-brain barrier publication-title: FEBS J. doi: 10.1111/febs.13412 – volume: 87 start-page: 243 year: 2010 ident: 10.1016/j.bbrc.2018.12.144_bib16 article-title: Role of GTPases in control of microvascular permeability publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvq086 – volume: 103 start-page: 40 year: 2010 ident: 10.1016/j.bbrc.2018.12.144_bib15 article-title: Driving Rho GTPase activity in endothelial cells regulates barrier integrity publication-title: Thromb. Haemostasis doi: 10.1160/TH09-06-0403 |
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| SubjectTerms | actin Blood-brain barrier caudal vein endothelial cells hippocampus males metalloproteinases METH methamphetamines microfilaments myosin light chains neurotoxicity permeability phosphorylation rats RhoA/ROCK pathway Tight junction tight junctions |
| Title | Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway |
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