Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha

• Published in: International journal of molecular sciences Vol. 22; no. 18; p. 9819
• Main Authors: Yun, Ba Da, Son, Seung Wan, Choi, Soo Young, Kuh, Hyo Jeong, Oh, Tae-Jin, Park, Jong Kook
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10.09.2021; MDPI
• Subjects: ABC transporters; Angiogenesis; Antitumor activity; Apoptosis; Breast cancer; Cancer; Cancer therapies; Cell cycle; Cell growth; Clinical trials; Colorectal cancer; Drug resistance; HIF; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-inducible factor 1a; Kinases; Liver cancer; Lung cancer; Metastasis; naturally derived compounds; normoxia; phytochemical; Phytochemicals; Plants; Proteins; Review; Vascular endothelial growth factor

Hypoxia-inducible factor-1 alpha (HIF-1α) is overexpressed in cancer, leading to a poor prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in hypoxia and even in non-hypoxic conditions, affecting its progression and malignant characteristics by regulating the expr...