Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23

• Published in: Cell metabolism Vol. 33; no. 7; pp. 1358 - 1371.e5
• Main Authors: He, Zhengxiang, Chen, Lili, Catalan-Dibene, Jovani, Bongers, Gerold, Faith, Jeremiah J., Suebsuwong, Chalada, DeVita, Robert J., Shen, Zeli, Fox, James G., Lafaille, Juan J., Furtado, Glaucia C., Lira, Sergio A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.07.2021
• Subjects: Allura Red; Animals; azo bonddye; Bacteria - metabolism; CD4+ T cells; colitis; Colitis - genetics; Colitis - metabolism; Colitis - microbiology; Disease Models, Animal; food additives; food colorants; Food Coloring Agents - adverse effects; Food Coloring Agents - metabolism; Genetic Predisposition to Disease; Homeodomain Proteins - genetics; IFN-γ; IL-23; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - microbiology; Interferon-gamma - genetics; Interleukin-23 - genetics; Interleukin-23 - metabolism; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; metabolites; Mice; Mice, Inbred C57BL; Mice, Knockout; microbiota; Symbiosis; microbiota; azo bonddye; IFN-γ; colitis; food additives; CD4+ T cells; food colorants; IL-23; metabolites; Allura Red; CD4(+) T cells

Both genetic predisposition and environmental factors appear to play a role in inflammatory bowel disease (IBD) development. Genetic studies in humans have linked the interleukin (IL)-23 signaling pathway with IBD, but the environmental factors contributing to disease have remained elusive. Here, we...