Antibody against a ring-infected erythrocyte surface antigen in cerebral and non-cerebral malaria patients

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 82; no. 3; pp. 385 - 388
• Main Authors: Tharavanij, Savanat, Tapchaisri, Pramuan, Mahakunkijcharoen, Yuvadee, Looareesuwan, Sornchai
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1988; Royal Society of Tropical Medicine and Hygiene; Elsevier
• Subjects: Animals; Antibodies, Protozoan - analysis; Biological and medical sciences; Brain Diseases - immunology; Fluorescent Antibody Technique; Human protozoal diseases; Humans; Infectious diseases; Malaria; Malaria - immunology; Medical sciences; Nervous system involvement in other diseases. Miscellaneous; Neurology; Parasitic diseases; Plasmodium falciparum; Protozoal diseases; Tropical medicine; Human; Brain; Protozoal disease; Nervous system diseases; Malaria; Antibody; Indirect immunofluorescence; Thailand; Cell surface; Immunological method; Infection; Antigen; Asia; Intraerythrocytic cycle; Humoral immunity
• ISSN: 0035-9203; 1878-3503
• DOI: 10.1016/0035-9203(88)90128-9

An indirect fluorescent antibody test for glutaraldehyde-fixed, ring-infected erythrocyte surface antigen was performed on admission sera from 45 patients with complicated cerebral Plasmodium falciparum malaria, 33 with uncomplicated cerebral malaria, 91 non-cerebral malaria patients, and 53 blood donors from a non-malarious area. 14 (31%), 28 (85%), 64 (70%), and 1 (2%), respectively, had titres ⩾ 1 25 , considered as positive. The seropositive rate and the geometric mean reciprocal titre of patients with complicated cerebral malaria were significantly lower than those of uncomplicated and non-cerebral patients, particularly in the 6–14 and 15–29 year age groups. Compared with non-cerebral patients, lower seropositive rates for patients with complicated cerebral malaria were demonstrated only in those who had been ill 4 or more days before admission; whereas lower rates for patients with complications, when compared with rates in those with uncomplicated cerebral malaria, occurred irrespective of the duration of illness.