Extracellular Vesicles in Synovial Fluid from Rheumatoid Arthritis Patients Contain miRNAs with Capacity to Modulate Inflammation

• Published in: International journal of molecular sciences Vol. 22; no. 9; p. 4910
• Main Authors: Foers, Andrew D., Garnham, Alexandra L., Chatfield, Simon, Smyth, Gordon K., Cheng, Lesley, Hill, Andrew F., Wicks, Ian P., Pang, Ken C.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.05.2021; MDPI
• Subjects: Apoptosis; Arthritis; Attenuation; Cell growth; Cytokines; Extracellular vesicles; Gene expression; Genes; Inflammation; Interleukin 6; Joint diseases; Joints (anatomy); MicroRNAs; miRNA; Oxygen enrichment; Pathophysiology; Patients; Proteins; Reactive oxygen species; Rheumatoid arthritis; RNA polymerase; Signal transduction; Size exclusion chromatography; Stat3 protein; Synovial fluid; Transcription; Vesicles

In rheumatoid arthritis (RA), extracellular vesicles (EVs) are associated with both the propagation and attenuation of joint inflammation and destruction. However, the specific EV content responsible for these processes is largely unknown. Investigations into identifying EV content are confounded by...