The c-kit receptor ligand functions as a mast cell chemoattractant

• Published in: Blood Vol. 79; no. 4; pp. 958 - 963
• Main Authors: MEININGER, C. J, YANO, H, ROTTAPEL, R, BERNSTEIN, A, ZSEBO, K. M, ZETTER, B. R
• Format: Journal Article
• Language: English
• Published: Washington, DC The Americain Society of Hematology 15.02.1992
• Subjects: Animals; Biological and medical sciences; Cell Movement; Cell physiology; Chemotactic Factors - pharmacology; Chemotaxis; Fundamental and applied biological sciences. Psychology; Hematopoietic Cell Growth Factors - pharmacology; Interleukin-3 - pharmacology; Mast Cells - physiology; Mice; Mice, Inbred C57BL; Molecular and cellular biology; Motility and taxis; Rats; Recombinant Proteins - pharmacology; Stem Cell Factor; Vertebrata; Mammalia; Mouse; Ligand; Animal; Rodentia; Mobility; Mast cell; Chemotaxis; Growth factor

Mast cells accumulate at sites of neovascularization, solid tumors, and many immune reactions. Such accumulation requires directed migration of mature mast cells or their precursors. The nature of the chemoattractants that regulate mast cell motility and the identity of the receptors that mediate th...